In this paper, we analyze several cancer cell types from two seemingly independent angles: (a) the over-expression of various proteins participating in protein-protein interaction networks and (b) a metabolic shift from oxidative phosphorylation to glycolysis. We use large data sets to obtain a thermodynamic measure of the protein-protein interaction network, namely the associated Gibbs free energy. We find a strong inverse correlation between the percentage of energy production via oxidative phosphorylation and the Gibbs free energy of the protein networks. The latter is a measure of functional dysregulation within the cell. Our findings corroborate earlier indications that signaling pathway upregulation in cancer cells is linked to the metabolic shift known as the Warburg effect; hence, these two seemingly independent characteristics of cancer phenotype may be interconnected.

中文翻译：

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蛋白质-蛋白质相互作用的吉布斯自由能与癌细胞中 ATP 的产生有关

在本文中，我们从两个看似独立的角度分析了几种癌细胞类型：（a）参与蛋白质 - 蛋白质相互作用网络的各种蛋白质的过度表达和（b）从氧化磷酸化到糖酵解的代谢转变。我们使用大数据集来获得蛋白质-蛋白质相互作用网络的热力学测量，即相关的吉布斯自由能。我们发现通过氧化磷酸化产生的能量百分比与蛋白质网络的吉布斯自由能之间存在很强的负相关。后者是细胞内功能失调的量度。我们的研究结果证实了早期的迹象，即癌细胞中的信号通路上调与称为 Warburg 效应的代谢转变有关。因此，