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Phenotypical and potential functional characteristics of different immune cells expressing CD28H/B7-H5 and their relationship with cancer prognosis.
Clinical & Experimental Immunology ( IF 3.4 ) Pub Date : 2020-02-04 , DOI: 10.1111/cei.13413
C Zhong 1 , Q Lang 1 , J Yu 1 , S Wu 1 , F Xu 1 , Y Tian 1
Affiliation  

CD28H and B7‐H5 have been identified as receptor–ligand pairs in the B7/CD28 family, and have co‐stimulatory activity in immune cells. Here, we have systematically reviewed the research reports concerning the CD28H/B7‐H5 pathway. It was found that CD28H is mainly expressed in T cells and natural killer (NK) cells with naive and poorly differentiated properties, and repeated antigen stimulation leads to permanent loss of CD28H. In tumors, CD28H is mainly expressed in tissue‐resident memory (TRM) lymphocyte T cells, which is associated with improved tumor prognosis. B7‐H5 is a ligand for CD28H and is widely expressed in tumor cells. B7‐H5 expression is closely related to the prognosis of the tumor. Studies have shown that high expression of B7‐H5 in tumor is related to a worse prognosis for lung cancer, osteosarcoma, oral squamous cell carcinoma (OSCC), breast carcinoma, human clear cell renal cell carcinoma (ccRCC), intrahepatic cholangiocarcinoma (ICC), bladder urothelial carcinoma (BUC) and colorectal cancer (CRC), but is associated with a better prognosis for pancreatic ductal adenocarcinoma (PDAC) and glioma. Controversial views exist in studies on gastric cancer prognosis.

中文翻译:

表达CD28H / B7-H5的不同免疫细胞的表型和潜在功能特征及其与癌症预后的关系。

CD28H和B7-H5在B7 / CD28家族中已被识别为受体-配体对,并且在免疫细胞中具有共刺激活性。在这里,我们系统地回顾了有关CD28H / B7-H5途径的研究报告。已经发现CD28H主要在T细胞和天然杀伤(NK)细胞中表达,其具有幼稚的和分化差的特性,并且反复的抗原刺激导致CD28H的永久丢失。在肿瘤中,CD28H主要在组织驻留记忆中表达(T RM)淋巴细胞T细胞,与肿瘤的预后改善有关。B7-H5是CD28H的配体,在肿瘤细胞中广泛表达。B7-H5的表达与肿瘤的预后密切相关。研究表明B7-H5在肿瘤中的高表达与肺癌,骨肉瘤,口腔鳞状细胞癌(OSCC),乳腺癌,人透明细胞肾细胞癌(ccRCC),肝内胆管癌(ICC)的预后较差有关,膀胱尿路上皮癌(BUC)和结直肠癌(CRC),但与胰腺导管腺癌(PDAC)和神经胶质瘤的预后较好相关。关于胃癌预后的研究存在争议。
更新日期:2020-03-26
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