Abstract

Facing the explosive growth of biological sequences unearthed in the post-genomic age, one of the most important but also most difficult problems in computational biology is how to express a biological sequence with a discrete model or a vector, but still keep it with considerable sequence-order information or its special pattern. To deal with such a challenging problem, the ideas of “pseudo amino acid components” and “pseudo K-tuple nucleotide composition” have been proposed. The ideas and their approaches have further stimulated the birth for “distorted key theory”, “wenxing diagram”, and substantially strengthening the power in treating the multi-label systems, as well as the establishment of the famous “5-steps rule”. All these logic developments are quite natural that are very useful not only for theoretical scientists but also for experimental scientists in conducting genetics/genomics analysis and drug development. Presented in this review paper are also their future perspectives; i.e., their impacts will become even more significant and propounding.

中文翻译：

---

关于分子遗传学和基因组学以及药物开发的一些启发性评论

摘要

面对后基因组时代出土的生物序列的爆炸性增长，计算生物学中最重要但也是最困难的问题之一是如何使用离散模型或载体表达生物序列，但仍然保持相当大的序列订单信息或其特殊模式。为了解决这样一个具有挑战性的问题，提出了“伪氨基酸成分”和“伪K-元组核苷酸组成”的思想。这些思想及其方法进一步激发了“失真关键理论”，“文兴图”的诞生，并大大增强了处理多标签系统的能力，并建立了著名的“五步法则”。所有这些逻辑发展都是很自然的，不仅在进行遗传学/基因组分析和药物开发方面对理论科学家和实验科学家都非常有用。这篇评论文章还介绍了他们的未来前景。也就是说，它们的影响将更加显着和令人鼓舞。