Abstract

Pregnancy-associated primary red cell aplasia (pPRCA) is a rare disorder that may occur at various time points during pregnancy. Unlike pregnancy-associated aplastic anemia, pPRCA is usually reversible, and no maternal deaths attributable to pPRCA have been reported. Herein, we report a woman diagnosed with pPRCA in two consecutive pregnancies. Corticosteroids were found to be ineffective, and she required a large number of red blood cell transfusions during both pregnancies. Despite severe anemia developing in both pregnancies, two healthy babies were vaginally born and spontaneous remission of pPRCA was seen after delivery. Interestingly, in both events of pPRCA described here, a transient rise of reticulocytes was observed precedent to the authentic recovery phase of reticulocytes and remission of pPRCA, which is a novel finding that has not been reported. The significance of this phenomenon has yet to be elucidated. Along with this case report, we review all 15 cases with 21 events of pPRCA in the literature, including the present case.

中文翻译：

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自限性妊娠相关的纯红细胞发育不良在两个连续的怀孕中发展：病例报告和文献复习。

摘要

与妊娠相关的原发性红细胞发育不全（pPRCA）是一种罕见的疾病，可能在怀孕期间的各个时间点发生。与妊娠相关的再生障碍性贫血不同，pPRCA通常是可逆的，并且没有报道可归因于pPRCA的孕产妇死亡。在此，我们报告了连续两次怀孕中被诊断患有pPRCA的女性。发现皮质类固醇无效，在两次妊娠期间她都需要输血大量红细胞。尽管两个孕妇均出现严重贫血，但有两个健康的婴儿阴道出生，分娩后可见pPRCA的自发缓解。有趣的是，在此处所述的两种pPRCA事件中，网状细胞的短暂升高是在网状细胞的真正恢复阶段和pPRCA缓解之前观察到的，这是一个尚未发现的新颖发现。这种现象的重要性尚待阐明。连同该病例报告，我们回顾了包括本例在内的所有15例21例pPRCA事件。