BackgroundEpidemiologic studies have demonstrated a relationship between selenium status and cancer risk among those with low selenium levels. It is of interest to prospectively evaluate the relationship between selenium and cancer among women who reside in a region with ubiquitously low selenium levels.MethodsWe performed a nested case-control study of baseline serum selenium levels and cancer risk using data and biological samples from 19,573 females that were participants in a biobanking initiative between 2010 and 2014 in Szczecin Poland. Cases included women with any incident cancer (n = 97) and controls (n = 184) were women with no cancer at baseline or follow-up. Serum selenium was quantified using mass spectroscopy.ResultsThe odds ratio associated being below the cutoff of 70.0 μg/L compared to a level above 70.0 μg/L was 2.29 (95% CI 1.26–4.19; P = 0.007). The risks for women in the two middle categories were similar and suggests that the normal range be between 70 μg/L and 90 μg/L. There was evidence for an increased risk of cancer among women in the highest category of selenium levels (i.e., > 90 μg/L), but this association did not achieve statistical significance (OR = 1.63; 95%CI 0.63–4.19; P = 0.31).ConclusionsResults from this study suggest that suggest that the optimum serum level of selenium in women living in Poland should be between 70 μg/L and 90 μg/L.

中文翻译：

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血清硒水平和癌症风险：一项巢式病例对照研究

背景流行病学研究表明，硒水平低的人群中硒状态与癌症风险之间存在相关性。前瞻性评估居住在硒水平普遍较低的地区的女性的硒与癌症之间的关系是有意义的。方法我们使用来自 19,573 名女性的数据和生物样本对基线血清硒水平和癌症风险进行了巢式病例对照研究他们是 2010 年至 2014 年在波兰什切青开展的生物样本库计划的参与者。病例包括患有任何癌症的女性（n = 97）和对照组（n = 184）是在基线或随访时没有癌症的女性。使用质谱对血清硒进行定量。结果与高于 70.0 μg/L 的水平相比，低于 70.0 μg/L 的临界值的优势比为 2.29（95% CI 1. 26–4.19；P = 0.007)。两个中间类别女性的风险相似，表明正常范围在 70 μg/L 和 90 μg/L 之间。有证据表明，硒水平最高（即 > 90 μg/L）的女性患癌症的风险增加，但这种关联没有达到统计学意义（OR = 1.63；95%CI 0.63–4.19；P = 0.31).结论 本研究结果表明，波兰妇女的最佳血清硒水平应在 70 μg/L 至 90 μg/L 之间。