Abstract

This study documented the etiology contributions between anxiety symptoms (AS) and depressive symptoms (DS) from ages 6–12 years. Teachers assessed AS and DS in 1112 twins at 5 time points. A genetic cross-lagged model was used to estimate genetic/environmental contributions to cross-sectional, cross-age and cross-lag associations. The variance in AS and DS was largely time-specific and more genetic in nature for DS than for AS. Previous DS predicted subsequent DS better than cross-lag or previous common effects, and AS up to age 9 better than previous AS or previous common effects. Thereafter, previous AS predicted subsequent AS. All predictions involved both genetic and unique environment. Suppression effects were found and, when controlled, AS marginally predicted DS from age 7 onward through genetic influences. AS and DS are associated throughout childhood. DS are more stable than AS, and more central to both subsequent AS and DS. AS marginally contribute to subsequent DS.

中文翻译：

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童年期焦虑与抑郁症状之间的纵向关联的遗传交叉滞后研究

摘要

这项研究记录了6至12岁之间焦虑症状（AS）和抑郁症状（DS）之间的病因学贡献。教师在5个时间点评估了1112对双胞胎的AS和DS。遗传交叉滞后模型用于估计遗传/环境对横断面，跨年龄和跨时滞关联的贡献。与AS相比，DS的AS和DS的差异很大程度上是特定于时间的，并且本质上来说，DS的遗传性更高。先前的DS预测后继的DS优于交叉滞后或先前的共同效应，并且9岁以下的AS优于先前的AS或先前的共同效应。此后，先前的AS预测了后续的AS。所有的预测都涉及遗传和独特的环境。发现了抑制作用，并且在受到控制的情况下，AS通过遗传影响从7岁开始微不足道地预测了DS。AS和DS在整个童年时期都相关。DS比AS更稳定，并且对于后续的AS和DS而言更重要。AS对后续DS的贡献很小。