ABSTRACT

The main objetive was to analyze the accuracy of different verbal fluency tests (VFTs) in discriminating cognitively healthy subjects from individuals with mild cognitive impairment (MCI) and probable Alzheimer’s disease (AD) in a cohort of older Spanish speaking adults. As a result, we aimed to identify the VFT that best predicts conversion from MCI to probable AD. 287 subjects: 170 controls (HC), 90 stable MCI and 27 patients with MCI that evolved into probable AD (MCI-AD) were assessed with a neuropsychological battery test and five VFTs. The animal fluency test produced the best differentiation of HC from MCI (p < .001), of HC from MCI-AD (p < .001) and of MCI from MCI-AD converters (p < .001), with sensitivities 98.8%, 98.8% and 75.6%, respectively. Logistic regression showed that the animal fluency test (p < 0.001) appears to be the most useful and neuropsychological VFT to predict conversion to probable dementia.

摘要

主要目标是分析不同语言流利性测试 (VFT) 在区分认知健康受试者与患有轻度认知障碍 (MCI) 和可能患有阿尔茨海默病 (AD) 的老年人群中的西班牙语老年人群中的准确性。因此，我们旨在确定最能预测从 MCI 到可能的 AD 转换的 VFT。287 名受试者：170 名对照 (HC)、90 名稳定的 MCI 和 27 名 MCI 演变为可能的 AD (MCI-AD) 的患者通过神经心理学电池测试和五个 VFT 进行评估。动物流畅性测试产生了 HC 与 MCI (p < .001)、HC 与 MCI-AD (p < .001) 和 MCI 与 MCI-AD 转换器 (p < .001) 的最佳区分，灵敏度为 98.8% ，分别为 98.8% 和 75.6%。Logistic 回归显示动物流畅性测试 (p < 0.