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Tapered photonic crystal fibers coated with ultra-thin films for highly sensitive bio-chemical sensing
Journal of the European Optical Society-Rapid Publications ( IF 1.9 ) Pub Date : 2019-05-08 , DOI: 10.1186/s41476-019-0103-6
Vladimir P. Minkovich , Alexander B. Sotsky

Photonic crystal fiber Mach-Zehnder modal interferometers based on no adiabatic tapered fibers are perspective for bio-chemical sensing, since they have very high refractive index sensitivity and it is possible for them to use a very small quantity of investigated samples. To obtain a desirable sensitivity to a needed analyte, it was proposed to coat a sensing surface of the refractive index sensor with ultra-thin films. In this work, we reported on a no adiabatic tapered special photonic crystal fiber coated with an ultra-thin layer of a Bovine Serum Albumin (BSA) antigen or with an 8 nm palladium film to detect interaction between the BSA antigen and an anti-BSA antibody or for fast detection of hydrogen concentrations, respectively. During our experiments, we received a record detection limit of 125 pg/ml of the anti-BSA antibody concentration. Fast detection of hydrogen concentrations up to 5.6 vol% was carried out. By using a proposed electrodynamics model of a hydrogen sensor, an optimal taper sensing length was determined.

中文翻译:

涂有超薄膜的锥形光子晶体光纤,用于高度灵敏的生物化学传感

基于无绝热锥形纤维的光子晶体光纤马赫曾德尔模态干涉仪是生物化学传感的理想之选,因为它们具有很高的折射率灵敏度,并且有可能使用很少量的被研究样品。为了获得对所需分析物的期望灵敏度,提出了用超薄膜覆盖折射率传感器的感测表面。在这项工作中,我们报道了一种无绝热的锥形特殊光子晶体光纤,该光纤涂有一层超薄的牛血清白蛋白(BSA)抗原或8 nm钯膜,以检测BSA抗原和抗BSA之间的相互作用抗体或快速检测氢浓度。在我们的实验中,我们收到的抗-BSA抗体浓度的检测极限为125 pg / ml。快速检测了高达5.6 vol%的氢浓度。通过使用提出的氢传感器的电动力学模型,确定了最佳的锥度感测长度。
更新日期:2020-04-23
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