Blood banking is a long and complex process requiring an accurate screening of potential donors and high-quality control systems. Previous studies in literature investigated factors potentially determining a higher cell levels with the aim of optimizing donors’ selection and improving banking process. This study aims to identify factors associated with the concentration of stem cells in umbilical cord blood, so increasing the probability of bankability, focusing on the possible implications in terms of obstetric and resources management. This is a retrospective study conducted in the Obstetric Units of two Italian Hospitals in Montebelluna and Castelfranco Veneto. Study has been conducted on cord blood units banked between 1999 and 2015. Data on medical histories and clinical characteristics of mother and baby have been retrieved via a retrospective examination of medical records. A total of 869 cord blood units were studied. At multivariable analysis, in agreement with literature, birthweight and placental weight have been found to be associated with higher concentration of total nucleated cells. As additional factor, amount of fluid infused was associated with cord blood units’ count. This study is the first one to clearly identify the role of fluid infusion on cord blood units’ counts in addition to placental weight and delivery. Some non-modifiable features can help in predicting bankability from pre-natal aspects to factors more related with obstetric management is suggested.

中文翻译：

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与血脐带单位可存储性相关的因素：对长达 15 年的案例系列的分析


血库是一个漫长而复杂的过程，需要准确筛选潜在献血者和高质量的控制系统。先前的文献研究调查了潜在决定较高细胞水平的因素，目的是优化捐赠者的选择和改进银行流程。本研究旨在确定与脐带血中干细胞浓度相关的因素，从而提高可存储性的可能性，重点关注对产科和资源管理方面可能产生的影响。这是一项在蒙特贝卢纳和威尼托自由堡两家意大利医院的产科单位进行的回顾性研究。研究对 1999 年至 2015 年间储存的脐带血单位进行了研究。通过回顾性检查病历，检索了母亲和婴儿的病史和临​​床特征数据。总共研究了 869 个脐带血单位。在多变量分析中，与文献一致，发现出生体重和胎盘重量与较高浓度的总有核细胞相关。作为附加因素，输注的液体量与脐带血单位计数相关。这项研究是第一个明确确定输液对胎盘重量和分娩之外的脐带血单位计数的作用的研究。建议一些不可修改的特征可以帮助预测从产前方面到与产科管理更相关的因素的可融资性。