Hepatorenal injuries and dyslipidemia are common global health challenges but medicinal plant extracts may have potential to prevent them. Thus, this study evaluated the protective effect of aqueous extract of Lophira lanceolata leaf (LLE) against cisplatin-induced hepatorenal injuries and dyslipidemia in albino Wistar rats. Thirty rats were randomly divided into 6 groups of 5 rats each. Group I rats received distilled water and served as control, group II rats were given 5 mg/kg cisplatin (CIS) intraperitoneally, groups III and IV rats were treated with 200 and 400 mg/kg LLE respectively for 26 days by oral gavages while groups V and VI rats were treated with 200 and 400 mg/kg LLE respectively, followed by CIS on the 21st day as in group II. About 24 h after treatment, blood was collected from the rats; then serum was separated and used for estimations of biochemical parameters. The kidney and liver of rats were removed, rinsed in normal saline, stored in 10% formalin and used for histological analyses. The biomarkers of hepatic (Aminotransferases, Alkaline phosphatase and Bilirubin) and renal (urea and creatinine) injuries, and dyslipidemia (Total cholesterol, triglycerides and LDL-cholesterol) significantly (p < 0.05) increased in the rats exclusively exposed to cisplatin when compared with normal control. However, treatment of cisplatin-exposed rats with 200 and 400 mg/kg LLE significantly (p < 0.05) reduced the levels of these biomarkers of hepatorenal injuries and dyslipidemia when compared with cisplatin control. Photomicrographs showed pathological signs in the liver and kidney of rats exclusively exposed to cisplatin, but there was moderate protection of these tissues in the rats treated with LLE and cisplatin. The current findings have shown that Lophira lanceolata leaf extract may provide moderate protection against cisplatin-induced hepatorenal injuries and dyslipidemia in albino Wistar rats.

中文翻译：

---

杉木叶水提取物对顺铂诱导的Wistar大鼠肝肾损伤和血脂异常的保护作用

肝肾损伤和血脂异常是全球普遍面临的健康挑战，但药用植物提取物可能具有预防它们的潜力。因此，本研究评估了柳叶枫叶水提取物（LLE）对白化Wistar大鼠中顺铂引起的肝肾损伤和血脂异常的保护作用。30只大鼠随机分为6组，每组5只。I组大鼠接受蒸馏水作为对照组，II组大鼠腹膜内给予5 mg / kg顺铂（CIS），III和IV组分别通过口服灌胃法和200 mg / kg LLE治疗26天，而II组对V和VI大鼠分别进行200和400 mg / kg LLE的治疗，然后在第21天进行CIS，与II组相同。治疗后约24小时，从大鼠中收集血液。然后分离血清并用于估计生化参数。取出大鼠的肾脏和肝脏，用生理盐水冲洗，保存在10％福尔马林中，用于组织学分析。与仅与顺铂接触的大鼠相比，仅接触顺铂的大鼠的肝脏（氨基转移酶，碱性磷酸酶和胆红素）和肾脏（尿素和肌酐）损伤以及血脂异常（总胆固醇，甘油三酸酯和LDL-胆固醇）的生物标志物显着增加（p <0.05）。正常控制。然而，与顺铂对照相比，用200和400 mg / kg LLE暴露于顺铂的大鼠治疗显着（p <0.05）降低了这些肝肾损伤和血脂异常生物标志物的水平。显微照片显示，仅暴露于顺铂的大鼠肝脏和肾脏有病理征象，但是在接受LLE和顺铂治疗的大鼠中，这些组织受到了中等程度的保护。目前的研究结果表明，轮叶罗菲拉叶提取物可能为白化Wistar大鼠对抗顺铂引起的肝肾损伤和血脂异常提供适度保护。