The gold standard treatment for periprosthetic joint infections is currently a 2-stage revision procedure with the use of antibiotic beads or cement spacer. We report the case of an elderly lady who had an infected total knee replacement and underwent a prosthesis retaining procedure with the use of antibiotic loaded calcium sulphate beads (stimulan in this case). Postoperatively, she became profoundly hypercalcaemic and lethargic. After other causes were excluded, she was taken for surgical washout of the knee joint. This led to prompt normalisation of serum calcium levels and resolution of her symptoms. We recommend the need for routine pre- and postoperative serial calcium measurements when using antibiotic impregnated calcium sulphate beads and that all doctors have an increased awareness of this risk.

中文翻译：

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在感染的全膝关节置换术中使用可溶性抗生素微珠后出现症状性高钙血症

目前，假体周围关节感染的金标准治疗是使用抗生素珠或水泥垫片的两阶段修复程序。我们报道了一位老年女士的案例，该女士患有感染性全膝关节置换术，并使用载有抗生素的硫酸钙珠子（在这种情况下为刺激剂）进行了假体保留手术。术后，她变得严重高钙血症和嗜睡。在排除了其他原因之后，她被接受了膝关节手术冲洗。这导致血清钙水平迅速正常化并缓解了她的症状。我们建议在使用抗生素浸渍的硫酸钙微珠时，需要对术前和术后进行常规的连续钙测量，并且所有医生都应对此危险性有更高的认识。