High expression of IGBP1 correlates with poor prognosis in esophageal squamous cell carcinoma,The International Journal of Biological Markers

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High expression of IGBP1 correlates with poor prognosis in esophageal squamous cell carcinoma
The International Journal of Biological Markers ( IF 2.3 ) Pub Date : 2019-12-25 , DOI: 10.1177/1724600819896374
Sicong Jiang ₁ , Daojing Li ₁ , Zibin Liang ₂ , Yanhua Wang ₁ , XiaoFeng Pei ₂ , Jianjun Tang _{1,

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Affiliation

Esophageal cancer remains one of the most virulent malignancies characterized by a high incidence and poor prognosis. Each year, an estimated 455,800 new esophageal cancer cases occur worldwide, with 400,200 expected deaths.^1,2 The global incidence burden and mortality are expected to continue to increase over time. Esophageal squamous cell carcinoma (ESCC) is the predominant pathological type of esophageal cancer in East Asia and belongs to the most frequent aggressive malignant cancers, which ranks as the fourth leading cause of cancer-related death in China.^3,4 Despite considerable advances achieved in diagnosis and multimodality therapies, the overall 5-year survival rate for esophageal cancer remains approximately 17%.^2,5 Previous reports have shown that genetic variations frequently associated with the development of esophageal cancer include the p53 mutation, the inactivation of p16, the amplification of cyclin D1, and the amplification of c-Myc or the epidermal growth factor receptor.^3,6,7 The carcinogenesis and development of esophageal cancer is a complex process that involves cumulative mutations or amplification in multiple genes. Therefore, its exact molecular pathogenesis is still unknown. It is as advantage to identify potential molecular biomarkers for predicting prognosis in the progression of ESCC at an early stage.

更新日期：2020-04-14

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