Acute myocardial infarction is a major cause of death and disability worldwide. This study was designed to elucidate the effect of resveratrol (RES) in isoproterenol (ISO)-challenged myocardial injury in rats. Male Sprague-Dawley rats were randomly allocated to four groups (10 rats/group): negative, control positive ISO (85 mg/kg), Propranolol/ISO, and RES/ISO. RES (50 mg/kg) improved plasma lactate dehydrogenase, creatine kinase, and cardiac troponin T; brain natriuretic peptide, interleukin-10, vascular endothelial growth factor, and transforming growth factor-β1; as well as cardiac superoxide dismutase, malondialdehyde, and total protein kinase-1 (Akt-1) levels. In addition, RES reduced the expression of cardiac inducible nitric oxide synthase and microRNA-34a, as well as p38 mitogen-activated protein kinase levels compared with positive control group. In conclusion, RES could reduce the degree of MI induced by ISO by improving the antioxidant, antiapoptotic, and anti-inflammatory capacities of the body.

中文翻译：

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白藜芦醇调节异丙肾上腺素诱导的心脏毒性中的miR-34a。

急性心肌梗塞是世界范围内死亡和残疾的主要原因。这项研究旨在阐明白藜芦醇（RES）在异丙肾上腺素（ISO）所致大鼠心肌损伤中的作用。将雄性Sprague-Dawley大鼠随机分为四组（每组10只大鼠）：阴性，对照阳性ISO（85 mg / kg），普萘洛尔/ ISO和RES / ISO。RES（50 mg / kg）改善血浆乳酸脱氢酶，肌酸激酶和心肌肌钙蛋白T；脑钠肽，白介素-10，血管内皮生长因子和转化生长因子-β1; 以及心脏超氧化物歧化酶，丙二醛和总蛋白激酶1（Akt-1）的水平。此外，与阳性对照组相比，RES降低了心脏诱导型一氧化氮合酶和microRNA-34a的表达，以及p38丝裂原激活的蛋白激酶水平。总之，RES可以通过提高机体的抗氧化，抗凋亡和抗炎能力来降低ISO诱发的MI程度。