ABSTRACT

Purpose: Examine brain structure and function in OBPP and relate to clinical outcomes to better understand the effects of decreased motor activity on early brain development.

Methods: 9 OBPP, 7 controls underwent structural MRI scans. OBPP group completed evaluations of upper-limb function and functional near-infrared spectroscopy (fNIRS) during motor tasks.

Results: Mean primary motor area volume was lower in both OBPP hemispheres. No volume differences across sides seen within groups; however, Asymmetry Ratio in supplementary motor area differed between groups. Greater asymmetry in primary somatosensory area correlated with lower ABILHAND-Kids scores. fNIRS revealed more cortical activity in both hemispheres during affected arm reach.

Conclusion: Cortical volume differences or asymmetry were found in motor and sensory regions in OBPP that related to clinical outcomes. Widespread cortical activity in fNIRS during affected arm reach suggests reorganization in both hemispheres and is relevant to rehabilitation of those with developmental peripheral and brain injuries.

摘要

目的：检查 OBPP 中的大脑结构和功能，并与临床结果相关联，以更好地了解运动活动减少对早期大脑发育的影响。

方法：9 名 OBPP，7 名对照者接受了结构 MRI 扫描。OBPP 小组在运动任务期间完成了上肢功能和功能性近红外光谱 (fNIRS) 的评估。

结果：两个 OBPP 半球的平均初级运动区体积均较低。组内没有观察到两侧的体积差异；然而，不同组间辅助运动区的不对称率不同。初级体感区域的不对称性与 ABILHAND-Kids 评分较低相关。fNIRS 显示在受影响的手臂伸展期间，两个半球的皮质活动更多。

结论：在与临床结果相关的 OBPP 运动和感觉区域中发现皮质体积差异或不对称。fNIRS 在受影响的手臂伸展期间广泛的皮质活动表明两个半球的重组，并且与发育性外周和脑损伤患者的康复相关。