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The influence of donor and recipient characteristics on allograft tendons: a systematic review
Cell and Tissue Banking ( IF 1.4 ) Pub Date : 2020-01-02 , DOI: 10.1007/s10561-019-09803-5
Mingyou Xu 1 , Haoran Zhang 1 , Xionggang Yang 1 , Feng Wang 1 , Li Yang 1 , Hao Zhang 1 , Yongcheng Hu 2
Affiliation  

Tendon allograft has been an important alternative graft option aside from autograft. The outcome of reconstruction surgery is determined by donor and recipient related factors. The purpose of this article was to identified all studies reporting donor and recipient characteristics, including the age and gender of donors, along with the age, gender, activity level and smoking status of recipients, that affect the biomechanical properties and post-transplantation outcomes of allograft tendons. The systematic study search was based on MEDLINE via PubMed, Embase and the Cochrane Library databases. The reference lists of the included studies were used for hand searching (snowballing). The searching process was performed by two independent investigators, using search MESH term: “tendon”, “allograft”, and “person”. Studies evaluating the influence of donor and recipient biological characteristics on the mechanical property and transplantation outcome of allograft were included. A total of 12 studies were selected for qualitative synthesis, including 6 studies evaluated the influence of donor characteristics, including age and gender, on the mechanical strength of tendon allograft. 6 studies assessed the influence of recipient characteristics, including age, gender, smoking status, and activity level, on the clinical outcome. As a conclusion, tendon allografts from donor younger than 40 years old were expected to have a higher mechanical property. Young patients or patients with a high level of activity were not recommended to receive allograft tendon when autograft is optional. There is no strong evidence supporting that neither donor or recipient gender affects the tendon allograft transplantation outcomes. Smoking history could increase the risk of complications.

中文翻译:

供体和受体特征对同种异体肌腱的影响:系统评价

除自体移植外,肌腱同种异体移植已成为重要的替代性移植选择。重建手术的结果取决于供体和受体的相关因素。本文的目的是确定所有报告捐赠者和接受者特征的研究,包括捐赠者的年龄和性别,以及接受者的年龄,性别,活动水平和吸烟状况,这些因素会影响捐赠者的生物力学特性和移植后结果。同种异体肌腱。系统的研究搜索基于MEDLINE,通过PubMed,Embase和Cochrane图书馆数据库进行。纳入研究的参考文献清单用于手搜索(雪球运动)。搜索过程由两名独立的研究人员使用搜索MESH术语进行:“肌腱”,“同种异体移植”和“人”。包括评估供体和受体生物学特性对同种异体移植物力学性能和移植结果影响的研究。总共选择了12项研究进行定性合成,其中6项研究评估了供体特征(包括年龄和性别)对同种异体肌腱机械强度的影响。6项研究评估了接受者特征(包括年龄,性别,吸烟状况和活动水平)对临床结局的影响。结论是,来自40岁以下供体的肌腱同种异体移植物具有更高的机械性能。如果选择自体移植,不建议年轻患者或活动量高的患者接受同种异体肌腱。没有强有力的证据支持捐赠者或接受者的性别都不会影响肌腱同种异体移植的结果。吸烟史可能增加并发症的风险。
更新日期:2020-01-02
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