Developing a multiple functional wound dressing suitable for different stages of wound healing is important for patients with special wound such as burn or decubital ulcers. In this study, poly (vinyl alcohol) (PVA), dextran, and chitosan are integrated to produce ideal wound dressing where glutaraldehyde (GA) is used as the cross-linker. The result demonstrated that 6% PVA hydrogel with 0.25% chitosan was found to provide antimicrobial ability. The PVA/chitosan hydrogel combined with 4% dextran utilizing GA cross-linking also presents the high cell proliferation ability, which suggests that the hydrogel is potential as a wound dressing. In the following physical analyses, the addition of chitosan and dextran appeared to promote the thermostability, mechanical properties, water retention, and moisturizing ability in the PVA hydrogel. In conclusion, the PVA/chitosan/dextran hydrogel has promising potential such as high water content, antimicrobial property, and well cell proliferation, which can be applied to wound healing application.

中文翻译：

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PVA/葡聚糖/壳聚糖水凝胶用于伤口敷料的评价

开发适用于不同伤口愈合阶段的多功能伤口敷料对于烧伤或褥疮等特殊伤口的患者非常重要。在这项研究中，聚（乙烯醇）（PVA）、葡聚糖和壳聚糖被整合以生产理想的伤口敷料，其中戊二醛（GA）用作交联剂。结果表明，发现含有 0.25% 壳聚糖的 6% PVA 水凝胶具有抗菌能力。PVA/壳聚糖水凝胶结合4%葡聚糖，利用GA交联也表现出高细胞增殖能力，这表明该水凝胶具有作为伤口敷料的潜力。在以下物理分析中，加入壳聚糖和葡聚糖似乎可以提高 PVA 水凝胶的热稳定性、机械性能、保水性和保湿能力。综上所述，