Oxidative stress is significantly associated with chronic arsenic exposure in persons exposed to moderate-to-high level of environmental arsenic. However, the response varies widely among persons within similar exposure level. To study whether Glutathione-S-Transferase (GST) gene polymorphism plays any pivotal role in this variation, total number of 115 chronic arsenic-exposed study subjects without arsenic-induced cancer from School of Tropical Medicine, Kolkata and from arsenic-exposed districts of West Bengal were recruited for this study. Concentration of arsenic in their urine and water, extent of clinical manifestation, GST status and protein carbonylation, and 8-oxo-2′-deoxyguanosine status were determined. Genetic polymorphism of GSTM1 and T1 were significantly associated (p < 0.05) with degree of protein carbonylation and 8-oxo-2′-deoxyguanosine in moderate-to-high degree of arsenic exposure groups. Persons having null genotype have significantly increased level of protein carbonylation and 8-oxo-2′-deoxyguanosine in comparison to persons with GSTM1 or GSTT1 non-null genotype of the same arsenic exposure group. Degree of protein carbonylation and urinary 8-oxo-2-deoxyguanosine is positively correlated with GST null genotype.

中文翻译：

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谷胱甘肽-S-转移酶多态性对砷诱导的蛋白质羰基化和尿中脱氧鸟苷状态的影响

氧化应激与暴露于中度至高水平环境砷的人的慢性砷暴露显着相关。但是，在暴露水平相似的人群中，其反应差异很大。为了研究谷胱甘肽-S-转移酶（GST）基因多态性在这种变异中是否起关键作用，加尔各答热带医学院和来自砷暴露地区的115名没有砷诱发癌症的慢性砷暴露研究对象总数西孟加拉邦被招募参加这项研究。测定其尿液和水中的砷浓度，临床表现程度，GST状况和蛋白质羰基化程度以及8-oxo-2'-deoxyguanosine状况。GSTM1和T1的遗传多态性显着相关（p <0.05）在中等至高度砷暴露组中具有蛋白质羰基化程度和8-oxo-2'-脱氧鸟苷。与具有相同砷暴露组的GSTM1或GSTT1非空基因型的人相比，具有空基因型的人的蛋白质羰基化水平和8-oxo-2'-脱氧鸟苷水平显着提高。蛋白羰基化程度和尿中的8-氧-2-脱氧鸟苷与GST无效基因型正相关。