Heat shock proteins (Hsps) are widely reported in normal cellular dynamics under stress and non-stress conditions, and parallelly, the studies regarding its role in disease condition are also progressing steadily. The function of Hsps in neurodegenerative disorders is puzzling and not fully understood. This review aims to focus on the role of Hsp27 in normal and diseased conditions and emphasize its therapeutic potential. Hsp27, in particular, has shown to be involved in cell viability and actin cytoskeleton remodeling and also shown to improve many disease conditions. Phosphorylated Hsp27 modulates the p53 pathway by downregulating cellular senescence and also lowers reactive oxygen species to protect TNFα-mediated apoptosis. Hsp27 is also known to interfere with mitochondria-dependent and mitochondria-independent cell apoptotic stimulation. This article will highlight the various functions of Hsp27 especially as an anti-apoptotic factor and stress response factor and its therapeutic potential in preventing neuronal apoptosis in neurological diseases. This review also includes a comparison of the therapeutic potential of Hsp27 with regard to other small Hsps.

中文翻译：

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Hsp27 在神经系统疾病中的治疗潜力

热休克蛋白（Hsps）在应激和非应激条件下的正常细胞动力学中被广泛报道，同时，关于其在疾病状态中作用的研究也在稳步推进。Hsps 在神经退行性疾病中的功能令人费解且尚未完全了解。本综述旨在关注 Hsp27 在正常和患病条件下的作用，并强调其治疗潜力。特别是 Hsp27 已显示参与细胞活力和肌动蛋白细胞骨架重塑，并且还显示可改善许多疾病状况。磷酸化 Hsp27 通过下调细胞衰老来调节 p53 通路，并降低活性氧以保护 TNFα 介导的细胞凋亡。还已知 Hsp27 会干扰线粒体依赖性和线粒体非依赖性细胞凋亡刺激。本文将重点介绍 Hsp27 的各种功能，尤其是作为抗凋亡因子和应激反应因子的各种功能及其在预防神经系统疾病中神经元凋亡方面的治疗潜力。本综述还包括对 Hsp27 与其他小 Hsps 治疗潜力的比较。