Organoid and organ-on-a-chip have evolved as two critical but distinct approaches to develop human physiologically and pathologically relevant in vitro models. Although rapid progress has been witnessed in the past decade, there is no systematic comparison of their status and trends based on the scientometric analysis. In this study, we performed a comparative study of organoid and organ-on-a-chip using bibliometric methods. A total of 2790 documents published between 2009 and 2018 were retrieved and analyzed. Our results showed that both organoid and organ-on-a-chip had experienced rapid growth in their academic and social impacts and influenced a wide spectrum of disciplines, but with a major distinct focus on Cell Biology and Nanoscience Nanotechnology, respectively. The hotspots of organoid research were expanding from in vitro differentiation of Lgr5 stem cells to mechanistic studies of diseases, while the hotspots of the organ-on-a-chip research were transiting from the establishment of microfluidic devices for in vitro cell culture to stem cell differentiation and tissue engineering. Interestingly, there was a growing trend of combining organoid with organ-on-a-chip in the last few years. This comparative study presented a unique perspective to understand the evolutive history and future trends of organoid and organ-on-a-chip for emerging human relevant in vitro organotypic models.

中文翻译：

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过去十年来，全球类器官和片上器官的全球趋势：文献计量和比较研究。

器官和单片器官已发展成为两种重要的但截然不同的方法，可在体外发展人体的生理和病理学相关性楷模。尽管在过去的十年中见证了快速的进步，但是基于科学的计量分析，还没有系统地比较它们的状态和趋势。在这项研究中，我们使用文献计量法对类器官和芯片上的器官进行了比较研究。检索并分析了2009年至2018年之间发布的2790份文档。我们的研究结果表明，类器官和芯片上的器官在学术和社会方面均经历了快速增长，并影响了广泛的学科，但分别侧重于细胞生物学和纳米科学纳米技术。类器官的研究热点正在从体外扩展Lgr5干细胞的分化到疾病的机理研究，而单片器官研究的热点正从建立用于体外细胞培养的微流控设备过渡到干细胞分化和组织工程。有趣的是，在过去的几年中，将类器官与芯片上的器官结合在一起的趋势正在增长。这项比较研究提出了独特的观点，以了解新兴人类相关体外器官型模型的类器官和单片器官的进化历史和未来趋势。