Abstract

Estimated heritability of coffee intake ranges from 0.36 to 0.58, however, these point estimates assume that inherited effects are the same throughout the distribution of coffee intake, i.e., whether consumption is high or low relative to intake in the population. Quantile regression of 4788 child–parent pairs and 2380 siblings showed that offspring–parent and sibling concordance became progressively greater with increasing quantiles of coffee intake. Each cup/day increase in the parents’ coffee intake was associated with an offspring increase of 0.020 ± 0.013 cup/day at the 10th percentile of the offsprings’ coffee intake (slope ± SE, NS), 0.137 ± 0.034 cup/day at their 25th percentile (P = 5.2 × 10^–5), 0.159 ± 0.029 cup/day at the 50th percentile (P = 5.8 × 10^–8), 0.233 ± 0.049 cup/day at the 75th percentile (P = 1.8 × 10^–6), and 0.284 ± 0.054 cup/day at the 90th percentile (P = 1.2 × 10^–7). This quantile-specific heritability suggests that factors that distinguish heavier vs. lighter drinkers (smoking, male sex) will likely manifest differences in estimated heritability, as reported.

中文翻译：

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分位数特定的遗传力可能解释了涉及咖啡消耗的基因-环境相互作用

摘要

咖啡摄入量的估计遗传力范围为0.36至0.58，但是，这些要点估计假设在咖啡摄入量的整个分布中遗传的影响是相同的，即相对于人口摄入量而言，摄入量是高还是低。4788对儿童-父母对和2380个兄弟姐妹的分位数回归表明，随着咖啡摄入量的增加，后代-父母和兄弟姐妹之间的协调性也逐渐提高。父母的咖啡摄入量每增加一杯/天，其后代的咖啡摄入量的第10个百分点（坡度±SE，NS），后代的咖啡摄入量就增加0.020±0.013杯/天，其后代增加0.137±0.034杯/天。第25个百分位数（P = 5.2×10 ^–5），第50个百分位数（P = 5.8×10 ^–8），则为0.159±0.029杯/天），在第75个百分位（P = 1.8×10 ^–6）时为0.233±0.049杯/天，在第90个百分率（P = 1.2×10 ^–7）时为0.284±0.054杯/天。据报道，这种分位数特异性遗传力表明，区分重度饮酒者和较轻度饮酒者（吸烟，男性）的因素可能会显示出估计的遗传力差异。