Multicomponent Reaction of Aldehydes, Amines and Oxalacetate Analogues Leading to Biologically Attractive Pyrrole Derivatives.,Mini-Reviews in Medicinal Chemistry

当前位置： X-MOL 学术 › Mini-Rev. Med. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Multicomponent Reaction of Aldehydes, Amines and Oxalacetate Analogues Leading to Biologically Attractive Pyrrole Derivatives.
Mini-Reviews in Medicinal Chemistry ( IF 3.3 ) Pub Date : 2020-05-31 , DOI: 10.2174/1389557520666200103123114
Stella Manta ₁ , Nikolaos Kollatos ₁ , Christos Mitsos ₁ , Georgia-Anna Chatzieffraimidi ₁ , Ioannis Papanastasiou ₂ , John K Gallos ₃ , Dimitri Komiotis _{1,

3}

Affiliation

Pyrrole is a very important pharmacophoric moiety. It has been widely incorporated into the skeleton of antitumor, anti-inflammatory, antibacterial, antioxidant and antifungal active substances. Access to this key heterocycle by diverse routes is particularly attractive in terms of chemistry, and also from the environmental point of view. The present minireview summarizes the reported methods for the preparation of highly substituted pyrrole derivatives based on the one-pot multicomponent reaction of aldehydes, primary amines, and oxalacetate analogues as well as their biology.

中文翻译：