Mechanical mismatch between vascular grafts and blood vessels is a major cause of smaller diameter vascular graft failure. To minimize this mismatch, several poly‐l‐lactide‐co‐ε‐caprolactone (PLC) copolymers are evaluated as candidate materials to fabricate a small diameter graft. Using these materials, tubular prostheses of 4 mm inner diameter are fabricated by dip‐coating. In vitro static and dynamic compliance tests are conducted, using custom‐built apparatus featuring a closed flow system with water at 37 °C. Grafts of PLC monomer ratio of 50:50 are the most compliant (1.56% ± 0.31∙mm Hg⁻²), close to that of porcine aortic branch arteries (1.56% ± 0.43∙mm Hg⁻²), but underwent high continuous dilatation (87 µm min⁻¹). Better matching is achieved by optimizing the thickness of a tubular conduit made from 70:30 PLC grafts. In vivo implantation and function of a PLC 70:30 conduit of 150 µm wall‐thickness (WT) are tested as a rabbit aorta bypass. An implanted 150 µm WT PLC 70:30 prosthesis is observed over 3 h. The recorded angiogram shows continuous blood flow, no aneurysmal dilatation, leaks, or acute thrombosis during the in vivo test, indicating the potential for clinical applications.

中文翻译：

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匹配小直径动脉的静态和动态顺应性与聚（丙交酯-己内酯）共聚物：体外和体内研究

血管移植物和血管之间的机械失配是较小直径的血管移植物衰竭的主要原因。为了最小化这种不匹配，若干聚升-lactide-共-ε -己内酯（PLC）的共聚物被评估为候选材料来制造小直径的移植物。使用这些材料，通过浸涂法制成内径为4 mm的管状假体。使用定制设备进行体外静态和动态合规性测试，该设备具有37°C的水的闭式流系统。PLC单体比例为50:50的移植物最顺应（1.56％±0.31∙mm Hg ^-2），接近猪主动脉分支动脉（1.56％±0.43∙mm Hg ^-2），但进行了高度连续扩张（最小87 µm ^-1）。通过优化由70:30 PLC移植物制成的管状导管的厚度，可以实现更好的匹配。壁厚为150 µm的PLC 70:30导管的体内植入和功能已作为兔主动脉旁路进行了测试。在3小时内观察到植入的150 µm WT PLC 70:30假体。所记录的血管造影照片显示在体内测试过程中持续的血流，无动脉瘤扩张，渗漏或急性血栓形成，表明其具有临床应用潜力。