Life makes extensive use of non-covalent interactions, as they are a convenient way to build complex structures that can be assembled or disassembled quickly, with a minimum energy consumption. Among the inter-molecular interactions, hydrogen bond plays a central role, and it is the main responsible of the structure of proteins, DNA, and several other superstructures in the cell. Characterization of hydrogen bond in biologic environment is not an easy task, and several complex and imaginative techniques have been developed to circumvent the technical challenges of such studies. We present here an overview of the field of mass-resolved laser spectroscopy applied to nucleobases, peptides, and monosaccharides to demonstrate that despite the different environment the molecules encounter in the jet, such experiments yield important structural information that helps understanding the role played by hydrogen bond in biology.

中文翻译：

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探索生物分子中的氢键

生命广泛使用非共价相互作用，因为它们是构建复杂结构的便捷方式，可以快速组装或拆卸，并且能耗最低。在分子间相互作用中，氢键起着核心作用，它是细胞内蛋白质、DNA和其他几种超结构的主要结构。生物环境中氢键的表征并非易事，已经开发了几种复杂而富有想象力的技术来规避此类研究的技术挑战。我们在此概述了应用于核碱基、肽和单糖的质量分辨激光光谱领域，以证明尽管分子在射流中遇到的环境不同，