The present study aimed to evaluate the influence of the IL1B -31C/T polymorphism on gastric inflammatory response and precancerous lesions development – atrophic gastritis (AG) and intestinal metaplasia (IM) – in patients positive for Helicobacter pylori infection with functional dyspepsia (FD). The diagnosis of FD followed the Rome III criteria, and the H. pylori infection was evaluated by urease test and histological examination of gastric biopsies (corpus, antrum, and incisura). The severity of chronic inflammation and inflammatory activity, as well as the presence of precancerous lesions were evaluated accordingly to the updated Sydney System. Genotyping of the IL1B -31C/T polymorphism (rs1143627) was performed by polymerase chain reaction-restriction fragment length polymorphism. A total of 303 patients positive for H. pylori infection with FD were analyzed (81.8% women; mean age of 46.3 ± 12.3 years). No differences were observed in overall genotype frequencies among outcomes evaluated. However, in the dominant -31C allele model (CC+CT vs. TT), the frequency of the TT genotype was significantly higher among patients with moderate/severe chronic inflammation of the antrum than the frequency of the CC+CT genotypes (80.8% vs. 65.2%; OR = 2.25; 95% CI = 1.23-4.24; P = .005). The presence of AG and IM in the gastric mucosa of patients was of 19.5% and 19.1%, respectively. No significant association was observed concerning the frequencies of the genotypes of IL1B -31C/T polymorphism with development of precancerous lesions. In conclusion, our data suggest that genetic variants of the IL1B -31C/T polymorphism play a role in chronic inflammation of the gastric mucosa in H. pylori-infected FD patients.

本研究旨在评估IL1B- 31C / T基因多态性对幽门螺杆菌感染伴功能性消化不良（FD）呈阳性的患者的胃炎性反应和癌前病变发展的影响-萎缩性胃炎（AG）和肠化生（IM）。。FD的诊断遵循Rome III标准，并通过尿素酶试验和胃活检组织（体，窦和切牙）的组织学检查评估幽门螺杆菌感染。根据更新的悉尼系统，对慢性炎症和炎症活动的严重性以及癌前病变的存在进行了评估。IL1B的基因分型通过聚合酶链反应-限制性片段长度多态性进行-31C / T多态性（rs1143627）。总共分析了303例FD阳性幽门螺杆菌感染的患者（女性为81.8％；平均年龄为46.3±12.3岁）。在评估的结果之间，总体基因型频率没有观察到差异。然而，在显性-31C等位基因模型（CC + CT与TT）中，患有中度/重度慢性胃窦炎的患者中TT基因型的频率显着高于CC + CT基因型的频率（80.8％vs. 65.2％； OR = 2.25； 95％CI = 1.23-4.24；P= .005）。患者胃粘膜中AG和IM的存在分别为19.5％和19.1％。没有观察到IL1B- 31C / T基因多态性的基因型频率与癌前病变发展的显着相关性。总之，我们的数据表明，IL1B -31C / T多态性的遗传变异在幽门螺杆菌感染的FD患者的胃粘膜慢性炎症中起作用。