Chronic spontaneous urticaria (CSU) is characterized by recurrent itchy weals and/or angioedema and is believed to be driven by mast cell activation. It was shown that excessive mast cell activation during anaphylaxis initiates contact activation, resulting in bradykinin release. Evidence for bradykinin release was never demonstrated in CSU.

中文翻译：

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慢性自发性荨麻疹缓激肽释放的证据

慢性自发性荨麻疹 (CSU) 的特征是复发性瘙痒和/或血管性水肿，据信是由肥大细胞激活引起的。结果表明，过敏反应期间过度的肥大细胞激活会启动接触激活，导致缓激肽释放。CSU 从未证明缓激肽释放的证据。