Abstract—

The paper is a systematic review of using the pharmaceutical substance, Carnoy’s solution, to reduce the number of recurrences of such tumors as keratocystic odontogenic tumor and ameloblastoma. These are benign yet aggressive jaw tumors with a high percentage of recurrences (up to 60–80%). Surgical treatment of the above-described lesions can be performed using: (1) marsupialization (recurrence rate up to 24.8%); (2) enucleation with or without adjunct therapy; therapy may include cryotherapy with liquid nitrogen (recurrence rate up to 23.1%), peripheral ostectomy (recurrence rate up to 20%), and bone cavity treatment with Carnoy’s solution (recurrence rate up to 6.6%); (3) marginal/segmental resection of the jaw (recurrence rate up to 2.5%). Despite the low percentage of recurrences when using marginal/segmental resection, this method requires a longer and more expensive anesthetic and surgical intervention as well as longer postoperative and rehabilitation periods. With the use of Carnoy’s solution, it became possible to reduce the risks of recurrence of keratocystic odontogenic tumors and ameloblastomas from 60–80 to 6.6‒11.5%. Worldwide today, not only Carnoy’s solution recommended by Cutler and Zollinger in 1933 is applied but also its modifications that are not inferior to the original substance in terms of removal efficiency of the remaining cystic cells. The safety of the use of the solution near the vessels and nerves is confirmed by works of a number of authors. It is concluded that, despite the large number of surgical treatments of both keratocystic odontogenic tumors and ameloblastomas, enucleation with the use of Carnoy’s solution is the optimal method of choice for these diseases.

中文翻译：

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Carnoy解决方案及其修改的使用，以减少角膜囊性成牙本质肿瘤和成釉细胞瘤手术切除后的复发次数：系统评价

摘要-

本文是对使用Carnoy溶液这种药用物质减少诸如角化囊性牙源性肿瘤和成釉细胞瘤等肿瘤的复发次数的系统综述。这些是良性但侵略性的颌骨肿瘤，复发率高（高达60–80％）。可以使用以下方法对上述病变进行手术治疗：（1）有袋化（复发率高达24.8％）；（2）摘除伴或不伴辅助疗法；疗法可能包括液氮冷冻疗法（复发率高达23.1％），外周骨切除术（复发率高达20％）和卡诺氏溶液骨腔治疗（复发率高达6.6％）；（3）颌骨的边缘/节段性切除（复发率高达2.5％）。尽管使用边缘/节段性切除术的复发率较低，该方法需要更长和更昂贵的麻醉和手术干预，以及更长的术后和康复时间。通过使用Carnoy的解决方案，可以将角膜囊性牙源性肿瘤和成釉细胞瘤的复发风险从60-80降低到6.6×11.5％。如今，在全球范围内，不仅应用了卡特勒和佐林格在1933年推荐的Carnoy解决方案，而且其修饰形式在去除其余囊性细胞方面也不逊于原始物质。许多作者的著作证实了在血管和神经附近使用该溶液的安全性。结论是，尽管对角化囊性牙源性肿瘤和成釉细胞瘤均进行了大量手术治疗，