Polymorphisms in the interleukin-10 (IL-10) gene have been studied in various ethnic groups for possible association with Behçet’s disease (BD). This study aimed to perform a meta-analysis of eligible studies to calculate the association of IL-10 polymorphisms with BD. A systematic literature search was carried out in PubMed, Embase, Web of Science, and Scopus databases to identify relevant publications, and extracted the respective results. Pooled odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the power of association with a random-effects model. A total of 19 articles, consisting of 10,626 patients and 13,592 controls were included in the meta-analysis. The meta-analysis revealed significant associations in allelic and genotypic test models of − 819 (C vs. T: OR = 0.691, P < 0.001; CC vs. TT: OR = 0.466, P < 0.001; CC + CT vs. TT: OR = 0.692, P < 0.001; and CC vs. CT + TT: OR = 0.557, P < 0.001), − 592 (C vs. A: OR = 0.779, P = 0.002; CC + AA vs. AA: OR = 0.713, P = 0.021; and CA vs. AA: OR = 0.716, P = 0.016), rs1518111 (G vs. A: OR = 0.738, P < 0.001; GG vs. AA: OR = 0.570, P < 0.001; GG + AG vs. AA: OR = 0.697, P < 0.001; GG vs. GA + AA: OR = 0.701, P < 0.001; and AG vs. GG: OR = 0.786, P = 0.004) and rs1554286 (C vs. T: OR = 0.582, P < 0.001; CC vs. TT: OR = 0.508, P < 0.001; CC + CT vs. TT: OR = 0.605, P < 0.001; CC vs. CT + TT: OR = 0.665, P = 0.012; and CT vs. TT: OR = 0.646, P = 0.001). However, we failed to find any association between − 1082 polymorphism and susceptibility of BD. This meta-analysis demonstrated that the interleukin-10 -819, − 596, rs1518111 and rs1554286 polymorphisms could be responsible against BD susceptibility, and should probably be regarded as a protective factor for Behçet’s disease.

中文翻译：

---

探索白塞病中 IL-10 多态性的关联：系统评价和荟萃分析

白细胞介素 10 (IL-10) 基因的多态性已在不同种族群体中进行了研究，可能与白塞病 (BD) 相关。本研究旨在对符合条件的研究进行荟萃分析，以计算 IL-10 多态性与 BD 的关联。在 PubMed、Embase、Web of Science 和 Scopus 数据库中进行了系统的文献检索，以识别相关出版物，并提取各自的结果。具有 95% 置信区间 (CI) 的汇总优势比 (OR) 用于评估与随机效应模型的关联能力。荟萃分析共纳入 19 篇文章，包括 10,626 名患者和 13,592 名对照。荟萃分析显示 - 819 的等位基因和基因型测试模型存在显着关联（C 与 T：OR = 0.691，P < 0.001；CC 与 TT：OR = 0.466，P < 0.001；CC + CT 与 TT：OR = 0.692，P < 0.001；和 CC 与 CT + TT：OR = 0.557，P < 0.001），- 592（C 与 A：OR = 0.779，P = 0.002；CC + AA 与 AA：OR = 0.713，P = 0.021；和 CA与 AA：OR = 0.716，P = 0.016），rs1518111（G 与 A：OR = 0.738，P < 0.001；GG 与 AA：OR = 0.570，P < 0.001；GG + AG 与 AA：OR = 0.697，P < 0.001；GG 与 GA + AA：OR = 0.701，P < 0.001；和 AG 与 GG：OR = 0.786，P = 0.004）和 rs1554286（C 与 T：OR = 0.582，P < 0.001 ；CC 与 TT：OR = 0.508，P < 0.001；CC + CT 与 TT：OR = 0.605，P < 0.001；CC 与 CT + TT：OR = 0.665，P = 0.012；以及 CT 与 TT：或 = 0.646，P = 0.001）。然而，我们未能发现 - 1082 多态性与 BD 易感性之间的任何关联。这项荟萃分析表明，白细胞介素 10 -819、-596、