Nanotechnology has the impending ability to improve the therapeutic potential of drugs and radiation-based treatment approaches for reducing cancerous cell death while curtailing collateral toxicity to non-cancerous cells. Among all metal nanomaterials, gold nanoparticles (AuNPs) are establishing themselves as an excellent radiosensitizer and serve as a multimodal modality due to their unique physicochemical properties. The primordial purpose of the work is to evaluate the synergistic effect and molecular level interaction of gamma (γ) radiation on human cervical cancer cell (HeLa) in the presence of AuNPs. Biocompatible AuNPs in combination with γ-radiation were found to exhibit elated cytotoxic effects on cancer cells as evidenced by cell-based assays. The implication of AuNPs facilitates the minimization of radiation dose employment on cultured cells. As per our experimental evaluation, the modus operandi of dual effectors ascertained that a higher amount of reactive oxygen species (ROS) plays a key role in cellular functionality collapse. In that scenario, it can be concluded that AuNP-mediated radiosensitization proved to be the plausible candidate for preclinical testing in nanoparticle-based radiotherapy.

中文翻译：

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金纳米粒子提高伽马射线对宫颈癌细胞的放射治疗指数

纳米技术即将能够提高药物和基于辐射的治疗方法的治疗潜力，以减少癌细胞死亡，同时减少对非癌细胞的附带毒性。在所有金属纳米材料中，金纳米粒子 (AuNPs) 因其独特的物理化学性质而成为一种极好的放射增敏剂，并作为一种多模态模式。这项工作的主要目的是评估在 AuNPs 存在下伽马 (γ) 辐射对人宫颈癌细胞 (HeLa) 的协同作用和分子水平相互作用。生物相容性 AuNPs 与 γ 辐射相结合，被发现对癌细胞表现出兴奋的细胞毒性作用，如基于细胞的测定所证明的那样。AuNPs 的含义有助于最大限度地减少对培养细胞的辐射剂量使用。根据我们的实验评估，双效应器的操作方式确定，较高量的活性氧 (ROS) 在细胞功能崩溃中起着关键作用。在这种情况下，可以得出结论，AuNP 介导的放射增敏被证明是纳米粒子放射治疗临床前测试的合理候选者。