The creation of multifunctional metal-based coordination complexes has been a hot topic in the fields of material science and biomedicine for their great potential application, metal–organic frameworks (MOFs) process the features of both coordination complexes and semiconductor materials might fit the requirements of the targeted materials. In this study, the assembly of the light-harvesting linker with La(III) ion produced a three-dimensional MOF [La₂(adda)₃(H₂O)₂]_n (1) (H₂adda = (2E,2′E)-3,3′-(anthracene-9,10-diyl) diacrylic acid), which could be applied as an effective catalyst for the Rhodamine B’s degradation. The treatment effect of compound 1 on exercise pain after total knee arthroplasty (TKA) on rat model was evaluated. The times of rats licking the surgery tissues was counted in the analgesic animal model. The content of the nicotinic acetylcholine receptors on presynaptic membrane was determined by RT-PCR. The possible binding interaction of the drug-like La(III) complex to the DNA structure has been further reviewed by molecular docking simulation.

中文翻译：

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一种新型的La（III）-MOF，可通过降低烟碱型乙酰胆碱受体的表达有效地降解染料并对全膝关节置换术后的运动疼痛产生保护作用。

多功能金属基配位化合物的创建一直是材料科学和生物医学领域的热门话题，因为它们具有巨大的潜在应用，金属有机框架（MOF）可以处理配位化合物的特征，而半导体材料则可能符合目标材料。在这项研究中，集光接头与La（III）离子的组装产生了三维MOF [La ₂（adda）₃（H ₂ O）₂ ] _n（1）（H ₂ adda =（2E， 2'E）-3,3'-（蒽-9,10-二基）二丙烯酸），可用作罗丹明B降解的有效催化剂。复方的治疗效果在大鼠模型上评估了关于全膝关节置换术（TKA）后运动疼痛的1。在止痛动物模型中计数大鼠舔手术组织的次数。通过RT-PCR测定突触前膜上的烟碱乙酰胆碱受体的含量。分子对接模拟进一步审查了类药物La（III）复合物与DNA结构的可能结合相互作用。