Biocompatible, small-sized but well-dispersed gold nanoparticles (Au NPs) remain a major challenge for their synthesis. Here a convenient solution impregnation technique is developed to prepare such Au NPs under the regulation of degummed silk fibroin fibers (SFFs) extracted from Bombyx mori cocoons. SFFs play multiple roles in the formation of Au NPs such as reactive substrate to capture AuCl₄^- ions by the chelation of -C = O, reducing agent for Au(0) by the reduction of -OH, and modifiers to render biocompatible Au NPs by some functional groups and biomolecules. The as-prepared Au NPs with a size of 7–10 nm are embedded in the solid SFF substrate, and can disperse well in the liquid system by the disintegration of SFFs into silk fibroin (SF) in a certain CaCl₂ solution. The biocompatible Au NPs exhibit uniform small size and distribute stably in both solid and solution states, which have distinctive properties and functional advantages, and bring great convenience to their storage and transportation.

具有生物相容性的小尺寸但分散良好的金纳米颗粒（Au NP）仍然是其合成的主要挑战。这里一个方便的解决方案的浸渍技术被显影从提取脱胶的丝纤蛋白纤维（SFFs）的调节下，以制备这样的金纳米粒子家蚕的茧。SFFs起到金纳米粒子的形成多个角色如反应基质以捕获AUCL ₄ ^-由-C = O的螯合离子，被-OH的还原还原剂将Au（0），和改性剂以使生物相容的金纳米粒子通过一些官能团和生物分子。制备的尺寸为7–10 nm的金纳米颗粒被嵌入固体SFF基质中，并且可以通过在一定的CaCl中将SFF分解成丝素蛋白（SF）来很好地分散在液体系统中₂解决方案。具有生物相容性的金纳米粒子具有均匀的小尺寸，并且在固态和溶液态均稳定分布，具有独特的性能和功能优势，为它们的储存和运输带来了极大的便利。