Single and repeated intra-articular injections in the tarsocrural joint with allogeneic and autologous equine bone marrow-derived mesenchymal stem cells are safe, but did not reduce acute inflammation in an experimental interleukin-1β model of synovitis.,Equine Veterinary Journal

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Single and repeated intra-articular injections in the tarsocrural joint with allogeneic and autologous equine bone marrow-derived mesenchymal stem cells are safe, but did not reduce acute inflammation in an experimental interleukin-1β model of synovitis.
Equine Veterinary Journal ( IF 2.4 ) Pub Date : 2019-12-10 , DOI: 10.1111/evj.13222
Aimée C Colbath ₁ , Steven W Dow ₂ , Leone S Hopkins ₃ , Jennifer N Phillips ₄ , C Wayne McIlwraith ₄ , Laurie R Goodrich ₄

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Allogeneic and autologous bone marrow‐derived mesenchymal stem cells (BMDMSCs) have been administered in equine joints for their anti‐inflammatory effects. However, allogeneic BMDMSC offer multiple clinical and practical advantages. Therefore, it is important to determine the relative effectiveness of allogeneic vs autologous BMDMSCs.

中文翻译：

用同种异体和自体马骨髓来源的间充质干细胞在跗脚关节单次和重复关节内注射是安全的，但在滑膜炎的实验性白细胞介素-1β模型中并没有减少急性炎症。

异基因和自体骨髓间充质干细胞 (BMDMSCs) 已用于马关节，以发挥抗炎作用。然而，同种异体 BMDMSC 具有多种临床和实用优势。因此，确定同种异体与自体 BMDMSC 的相对有效性非常重要。

更新日期：2019-12-10

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