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Essential Ingredients and Innovations in the Design and Analysis of Group-Randomized Trials
Annual Review of Public Health ( IF 21.4 ) Pub Date : 2020-04-02 , DOI: 10.1146/annurev-publhealth-040119-094027
David M Murray 1 , Monica Taljaard 2, 3 , Elizabeth L Turner 4 , Stephanie M George 1
Affiliation  

This article reviews the essential ingredients and innovations in the design and analysis of group-randomized trials. The methods literature for these trials has grown steadily since they were introduced to the biomedical research community in the late 1970s, and we summarize those developments. We review, in addition to the group-randomized trial, methods for two closely related designs, the individually randomized group treatment trial and the stepped-wedge group-randomized trial. After describing the essential ingredients for these designs, we review the most important developments in the evolution of their methods using a new bibliometric tool developed at the National Institutes of Health. We then discuss the questions to be considered when selecting from among these designs or selecting the traditional randomized controlled trial. We close with a review of current methods for the analysis of data from these designs, a case study to illustrate each design, and a brief summary.

中文翻译:


小组随机化试验的设计和分析中的基本要素和创新

本文回顾了小组随机试验的设计和分析中的基本要素和创新。自从1970年代末将这些方法引入生物医学研究界以来,这些方法的方法文献一直在稳定增长,我们对这些进展进行了总结。除了小组随机试验之外,我们还对两种紧密相关设计的方法进行了回顾,这两种方法分别是个体随机分组治疗试验和阶梯楔入群随机试验。在描述了这些设计的基本要素之后,我们将使用由美国国立卫生研究院开发的新型文献计量工具来回顾其方法演变中最重要的进展。然后,我们讨论从这些设计中进行选择或选择传统的随机对照试验时要考虑的问题。

更新日期:2020-04-21
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