BackgroundIn the present work, an electrochemical sensor for detection of paracetamol was fabricated by modifying a glassy carbon electrode (GCE) using multiwalled carbon nanotube (MWCNT) decorated with bismuth oxide (Bi2O3) based on using the drop dry technique.MethodsThe prepared composite electrode was characterized by scanning electron microscopy–energy dispersive X-ray spectroscopy (SEM–EDS), Fourier transform infrared spectroscopy (FT-IR), and cyclic voltammetry (CV). Electrochemical techniques such as cyclic voltammetry, chronoamperometry, and square wave voltammetry (SWV) were used to study the behavior of paracetamol.ResultsThe modification process improved the redox kinetics of paracetamol as shown by increased peak currents. The peak current varied linearly with increment of paracetamol concentration in the range of 0.02 to 28 μM with a sensitivity of 1.133 μA μM−1. A detection limit of 0.0052 μM was obtained.ConclusionThe proposed method was successfully applied to determination of paracetamol in biological samples with recoveries in the range 94.3–98.7%.

中文翻译：

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用氧化铋 (III) 装饰的多壁碳纳米管用于生物样品中解热镇痛药物扑热息痛的电化学检测

背景在目前的工作中，基于使用滴干技术，通过用氧化铋 (Bi2O3) 装饰的多壁碳纳米管 (MWCNT) 修饰玻碳电极 (GCE) 来制备用于检测扑热息痛的电化学传感器。方法制备的复合电极是通过扫描电子显微镜-能量色散 X 射线光谱 (SEM-EDS)、傅里叶变换红外光谱 (FT-IR) 和循环伏安法 (CV) 表征。循环伏安法、计时电流法和方波伏安法（SWV）等电化学技术被用来研究扑热息痛的行为。结果改性过程改善了扑热息痛的氧化还原动力学，表现为峰值电流增加。峰值电流随扑热息痛浓度在 0 范围内的增加呈线性变化。02 至 28 μM，灵敏度为 1.133 μA μM-1。检测限为0.0052 μM。结论该方法成功应用于生物样品中扑热息痛的测定，回收率在94.3%~98.7%之间。