Computation of Patterson’s D-statistic and its five-taxon derivatives are important phylogenetic methods for the quantification of reticulated evolution, yet are limited in application by the lack of a single, comprehensive program to efficiently perform all necessary calculations from common phylogenetic and population genetic program file formats. To increase accessibility for a broad range of researchers, we present a user-friendly program (COMP-D) that provides flexibility for incorporating heterozygous sites, implements multiple statistical methods, and aggregates results from multiple tests. Program augmentations also facilitate the detection of population-level introgression. COMP-D provides a threefold increase in speed relative to comparable software. It is implemented in C++ and released under the GNU General Public License v3.0. Source code is available for Linux/Mac OS X from: https://github.com/stevemussmann/Comp-D_MPI.

Patterson的D统计量及其五类分类衍生物的计算是量化网状进化的重要系统发育方法，但由于缺乏单个，全面的程序来有效地执行常见的系统发育和种群遗传程序的所有必要计算而受到应用的限制文件格式。为了增加广泛的研究人员的可访问性，我们提出了一个用户友好的程序（COMP-D），该程序可灵活地合并杂合位点，实施多种统计方法并汇总来自多个测试的结果。增强程序还有助于发现人口层次的渗入。与同类软件相比，COMP-D的速度提高了三倍。它用C ++实现，并根据GNU通用公共许可证v3.0发布。