Abstract

In the last few years, ecofriendly malic acid production has received a potential platform for the bio-based chemicals to replace the dependency of fossil based resources. The main goal of this paper is to explore the feasibility of efficient production of malic acid from cost effective alternative renewable byproducts as feedstock. To replace the traditional method of malic acid production from petroleum-based compounds such as maleic acid, the efficiency of fermentation technology for malic acid production using various microorganisms has been improved. To date, glucose is designated as the best substrate for malic acid production. However, few reviews concerning about malic acid production by employing various microbial strains were reported. The current knowledge on the biosynthesis of malic acid has assisted to improve malic acid production using various microbial strains. But, there is still need for the continuous production and replacement of low-cost substrates to increase the yield of malic acid. This review provides an overview about progress, achievements, merits, challenges and future perspectives in malic acid production from cost effective alternative substrates. Thus, malic acid production can be economical using renewable byproducts like crude glycerol by employing appropriate microorganism.

中文翻译：

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从可再生副产物微生物生产苹果酸的最新进展

摘要

在过去的几年中，绿色苹果酸的生产已经获得了一种潜在的平台，可以替代生物基化学物质对化石基资源的依赖。本文的主要目的是探讨从具有成本效益的替代性可再生副产物作为原料有效生产苹果酸的可行性。代替从石油基化合物例如马来酸生产苹果酸的传统方法，使用各种微生物生产苹果酸的发酵技术的效率已得到提高。迄今为止，葡萄糖被指定为生产苹果酸的最佳底物。然而，关于使用各种微生物菌株生产苹果酸的评论很少。关于苹果酸的生物合成的当前知识已帮助使用各种微生物菌株提高了苹果酸的产量。但是，仍然需要连续生产和替换低成本底物以提高苹果酸的产率。这篇综述概述了从具有成本效益的替代底物中生产苹果酸的进展，成就，优点，挑战和未来前景。因此，通过使用合适的微生物，使用可再生副产物如粗甘油可以经济地生产苹果酸。具有成本效益的替代底物在苹果酸生产中的挑战和未来前景。因此，通过使用合适的微生物，使用可再生副产物如粗甘油可以经济地生产苹果酸。具有成本效益的替代底物在苹果酸生产中的挑战和未来前景。因此，通过使用合适的微生物，使用可再生副产物如粗甘油可以经济地生产苹果酸。