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Synthesis and characterization of iron oxide nanoparticles decorated with carboxymethyl curdlan
Macromolecular Research ( IF 2.8 ) Pub Date : 2009 , DOI: 10.1007/bf03218667
Chang-Moon Lee , Hwan-Jeong Jeong , Eun-Mi Kim , Su-Jin Cheong , Eun-Hye Park , Dong Wook Kim , Seok Tae Lim , Myung-Hee Sohn

We have synthesized the SPION coated with CMC and investigated the stability in water,T 2 relaxation rate and cytotoxicity. The coating with CMC improved the stability in water and reduced the cytotoxicity to cell viability. Furthermore, the CMC-coated SPION showed superparamagnetic behaviors. The CMC-coated SPION may be used for cellular andin vivo imaging. When CMC are chemically modified for conjugation of specific ligand, the CMCcoated SPION may have a great potential for biomedical applications.

中文翻译:

羧甲基凝胶多糖修饰的氧化铁纳米粒子的合成与表征

我们已经合成了带有CMC的SPION涂层,并研究了其在水中的稳定性,T 2弛豫速率和细胞毒性。带有CMC的涂层改善了在水中的稳定性,并降低了对细胞活力的细胞毒性。此外,CMC涂层的SPION表现出超顺磁行为。涂有CMC的SPION可用于细胞和体内成像。当对CMC进行化学修饰以结合特定的配体时,CMC涂层的SPION在生物医学应用中可能具有巨大的潜力。
更新日期:2020-09-14
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