We have synthesized the SPION coated with CMC and investigated the stability in water,T ₂ relaxation rate and cytotoxicity. The coating with CMC improved the stability in water and reduced the cytotoxicity to cell viability. Furthermore, the CMC-coated SPION showed superparamagnetic behaviors. The CMC-coated SPION may be used for cellular andin vivo imaging. When CMC are chemically modified for conjugation of specific ligand, the CMCcoated SPION may have a great potential for biomedical applications.

中文翻译：

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羧甲基凝胶多糖修饰的氧化铁纳米粒子的合成与表征

我们已经合成了带有CMC的SPION涂层，并研究了其在水中的稳定性，T ₂弛豫速率和细胞毒性。带有CMC的涂层改善了在水中的稳定性，并降低了对细胞活力的细胞毒性。此外，CMC涂层的SPION表现出超顺磁行为。涂有CMC的SPION可用于细胞和体内成像。当对CMC进行化学修饰以结合特定的配体时，CMC涂层的SPION在生物医学应用中可能具有巨大的潜力。