Tissue-resident lymphocytes that lack expression of rearranged antigen receptors and are lineage negative for classical T and B cell markers are collectively known as innate lymphoid cells (ILCs). The ILC family is remarkably heterogeneous and exhibits plasticity; however, mature ILCs can be grouped based on their steady state expression of distinct surface receptors and transcription factors as well as production of signature cytokines following activation. The study of ILC subsets in mouse and human tissues has revealed that the elicitation and magnitude of their effector functions are determined by a combination of extrinsic cues specific to the niches in which they reside. In this short review, we will summarize some recent findings related to tissue-specific signals that govern ILC responses and localization.

中文翻译：

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有意识和免疫敏感性：先天性淋巴样细胞ni和电路。

缺乏重排抗原受体表达且经典T和B细胞标记阴性的组织驻留淋巴细胞统称为先天淋巴样细胞（ILC）。ILC家族非常异质，具有可塑性。但是，成熟的ILC可以根据它们在不同表面受体和转录因子的稳态表达以及激活后产生的特征性细胞因子进行分组。对小鼠和人体组织中的ILC子集的研究表明，其效应子功能的激发和强度是由特定于其栖息地的外部线索的组合决定的。在这篇简短的评论中，我们将总结一些与组织特异性信号有关的最新发现，这些信号控制ILC反应和定位。