PurposeCritical Care Nephrology is an emerging sub-specialty of Critical Care. Despite increasing awareness about the serious impact of acute kidney injury (AKI) and renal replacement therapy (RRT), important knowledge gaps persist. This report represents a summary of a 1-day meeting of the AKI section of the European Society of Intensive Care Medicine (ESICM) identifying priorities for future AKI research.MethodsInternational Members of the AKI section of the ESICM were selected and allocated to one of three subgroups: “AKI diagnosis and evaluation”, “Medical management of AKI” and “Renal Replacement Therapy for AKI.” Using a modified Delphi methodology, each group identified knowledge gaps and developed potential proposals for future collaborative research.ResultsThe following key research projects were developed: Systematic reviews: (a) epidemiology of AKI with stratification by patient cohorts and diagnostic criteria; (b) role of higher blood pressure targets in patients with hypertension admitted to the Intensive Care Unit, and (c) specific clearance characteristics of different modalities of continuous renal replacement therapy (CRRT).Observational studies: (a) epidemiology of critically ill patients according to AKI duration, and (b) current clinical practice of CRRT.Intervention studies:( a) Comparison of different blood pressure targets in critically ill patients with hypertension, and (b) comparison of clearance of solutes with various molecular weights between different CRRT modalities.ConclusionConsensus was reached on a future research agenda for the AKI section of the ESICM.

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第一届 AKI 圆桌会议报告：ESICM AKI 部门的倡议

目的重症监护肾病学是重症监护的新兴亚专业。尽管人们越来越意识到急性肾损伤 (AKI) 和肾脏替代疗法 (RRT) 的严重影响，但重要的知识差距仍然存在。本报告代表了欧洲重症监护医学学会 (ESICM) AKI 部分为期 1 天的会议摘要，确定了未来 AKI 研究的优先事项。方法 ESICM AKI 部分的国际成员被选择并分配给三个中的一个亚组：“AKI 诊断和评估”、“AKI 的医学管理”和“AKI 的肾脏替代治疗”。使用改进的德尔福方法，每个小组确定知识差距并为未来的合作研究制定潜在的建议。结果开发了以下关键研究项目： 系统评价：(a) AKI 的流行病学，按患者队列和诊断标准进行分层；(b) 高血压目标在重症监护室收治的高血压患者中的作用，以及 (c) 不同方式连续性肾脏替代治疗 (CRRT) 的具体清除特征。 观察性研究：(a) 危重患者的流行病学根据 AKI 持续时间，以及 (b) 目前 CRRT 的临床实践。 干预研究：(a) 高血压危重患者不同血压目标的比较，以及 (b) 不同 CRRT 之间不同分子量溶质清除率的比较模式。结论 就 ESICM 的 AKI 部分的未来研究议程达成了共识。