A low-cost Kodo millet bran residue was utilized as feedstock for the production of D (−) lactic acid (DLA) using Lactobacillus delbrueckii NBRC3202 under anaerobic condition. Data culled from a series of batch fermentation processes with different initial Kodo millet bran residue hydrolysate (KMBRH) and DLA concentrations were used for kinetic model development. Both simulated and experimental data were in good agreement for cell growth, KMBRH utilization, and DLA formation. The values of kinetic constants specific growth rate, (μ_m = 0.17 h⁻¹); growth (α_P = 0.96 g.g⁻¹) and non-growth (β_P = 1.19 g.g⁻¹.h⁻¹) associated constant for DLA production and the maximum specific KMBRH utilization rate, (q_{G, max} = 1.18 g.g⁻¹.h⁻¹) were in good agreement with the literature reports. Kinetic analysis elucidated that L. delbrueckii growth was predominantly influenced by KMBRH limitation and highly sensitive to DLA inhibition. Fed-batch fermentation studies demonstrated the existence of substrate and product inhibition paving the scope for process intensification.

低成本的科多谷糠残渣被用作在厌氧条件下使用德氏乳杆菌NBRC3202生产D（-）乳酸（DLA）的原料。使用不同的初始Kodo小米糠残渣水解物（KMBRH）和DLA浓度从一系列分批发酵过程中收集的数据用于动力学模型开发。模拟和实验数据在细胞生长，KMMBH利用和DLA形成方面都非常吻合。动力学常数比生长速率的值（_μm = 0.17 h ^-1）；生长（α _P = 0.96的gg ^-1）和非生长（β _P = 1.19的gg ^-1 ·H ^-1）DLA生产的相关常数和最大比KMBRH利用率（q _{G，最大值}= 1.18 gg ^-1 .h ^-1）与文献报道非常吻合。动力学分析表明，德氏乳杆菌的生长主要受KMBRH限制的影响，并且对DLA抑制高度敏感。分批补料发酵研究证明了底物和产物抑制作用的存在，为过程强化奠定了基础。