Abstract

Developing bioprotective materials with bactericidal activity is of great significance since it can effectively keep healthcare workers from infection by emerging infectious diseases; however, this is still a big challenge. Herein, we fabricate a novel rechargeable N-halamine antibacterial material by functionalizing electrospun poly(vinyl alcohol-co-ethylene) (EVOH) nanofibers with dimethylol-5,5-dimethylhydantoin (DMDMH). The premise of the design is that the N-halamine compound, DMDMH, can be covalently grafted on the nanofibers, endowing the EVOH nanofibrous membranes (ENM) with rechargeable and durable bactericidal activity. The as-prepared DMDMH functionalized ENM (EDNM) render rechargeable chlorination capacity (> 2000 ppm), high inactivation efficacy against bacteria (> 99.9999% within 3 min), high filtration efficiency (> 99.5%) under low air resistance, and robust mechanical properties, which are due to the synergistic effect of the unique characters of N-halamines and electrospun nanofibrous architecture. The successful synthesis of the N-halamine antibacterial membranes can serve as a functional layer of protective equipment that capable of inactivating and intercepting pathogenic bioaerosols, providing new ways into the development of new-generation antibacterial bioprotective materials.

Graphic Abstract

中文翻译：

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具有可充电抗菌活性的N-哈拉明功能化电纺丝聚（乙烯醇-乙烯-乙烯）纳米纤维膜，具有生物保护作用。

摘要

开发具有杀菌活性的生物保护材料具有重要意义，因为它可以有效地防止医护人员受到新发传染病的感染。但是，这仍然是一个很大的挑战。本文中，我们通过用二羟甲基-5,5-二甲基乙内酰脲（DMDMH）功能化电纺制的聚乙烯醇-共-乙烯（EVOH）纳米纤维来制造新型可充电N-卤胺抗菌材料。设计的前提是N卤代胺化合物DMDMH可共价接枝到纳米纤维上，赋予EVOH纳米纤维膜（ENM）具有可充电和持久的杀菌活性。所制备的DMDMH功能化ENM（EDNM）具有可充电的氯化能力（> 2000 ppm），对细菌的高灭活效果（3分钟内> 99.9999％），在低空气阻力下的高过滤效率（> 99.5％）和坚固的机械性能性能，这是由于N-卤胺的独特特性与电纺纳米纤维结构的协同作用所致。N的成功合成卤胺抗菌膜可作为保护设备的功能层，能够灭活和拦截病原性生物气溶胶，为开发新一代抗菌生物保护材料提供了新途径。

图形摘要