Background. The role of RAD51 gene polymorphisms with the development of head and neck cancer (HNC) and esophageal cancer (EC) remains controversial. This meta-analysis was conducted to evaluate the correlation between the RAD51 polymorphisms and these two cancers quantitatively. Methods. Databases of PubMed, Web of Science, and Embase were used to search relevant papers prior to August 17, 2019. STATA 11.0 was performed to observe the correlation. Results. Ten relevant papers were enrolled in our analysis. Overall, a significant correlation was observed between the rs1801320 polymorphism and the increased risk of these two cancers (, for C vs. G; , for CG vs. GG; and , for CC+CG vs. GG). In subgroup analyses, an increased risk was found for EC (, for C vs. G; , for CC vs. GG; and , for CC vs. CG+GG), but not for HNC. Moreover, our analysis revealed that no statistical evidence of correlation was discovered between the polymorphism of rs1801321 and the increased risk of HNC. However, stratified analysis based on ethnicity suggested that rs1801321 polymorphism was related to the decreased risk of HNC among Caucasians (, for T vs. G). Conclusions. rs1801320 polymorphism was strongly associated with the risk of these two associated cancers, especially with esophageal cancer. Moreover, our results revealed that rs1801321 polymorphism was correlated to the decreased risk of HNC among Caucasians.

中文翻译：

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RAD51基因的遗传多态性与头颈癌和食道癌的风险：荟萃分析

背景。RAD51 基因多态性在头颈癌 (HNC) 和食管癌 (EC) 发展中的作用仍存在争议。进行该荟萃分析以定量评估 RAD51 多态性与这两种癌症之间的相关性。方法。在 2019 年 8 月 17 日之前使用 PubMed、Web of Science 和 Embase 的数据库搜索相关论文。执行 STATA 11.0 以观察相关性。结果。十篇相关论文被纳入我们的分析。总体而言，观察到 rs1801320 多态性与这两种癌症风险增加之间存在显着相关性（, 对于 C 与 G；, 对于 CG 与 GG；和, 对于 CC+CG 与 GG）。在亚组分析中，发现 EC 的风险增加（, 对于 C 与 G；, 对于 CC 与 GG；和, 对于 CC 与 CG+GG），但不适用于 HNC。此外，我们的分析表明，没有发现 rs1801321 的多态性与 HNC 风险增加之间存在相关性的统计证据。然而，基于种族的分层分析表明，rs1801321 多态性与高加索人 HNC 风险降低有关。, 对于 T 与 G）。结论。rs1801320 多态性与这两种相关癌症的风险密切相关，尤其是食管癌。此外，我们的研究结果表明，rs1801321 多态性与高加索人 HNC 风险降低相关。