The presence of a conductive component in bone scaffolds can be helpful in facilitating the intracellular electrical signaling among cells as well as improving bone healing when electromagnetic stimulation is applied. In this study, poly(3,4-ethylenedioxythiophene): poly(4-styrene sulfonate) as a biocompatible conductive polymer was incorporated into a hard tissue scaffold made of gelatin (Gel) and bioactive glass. The in vitro results revealed that incorporation of an optimized amount of poly(3,4-ethylenedioxythiophene): poly(4-styrene sulfonate) into the scaffold composition enhanced cell viability more than four times after 14 days incubation, compared to the scaffold without poly(3,4-ethylenedioxythiophene): poly(4-styrene sulfonate). The in vivo studies demonstrated the amount of new bone formation of Gel/bioactive glass/poly(3,4-ethylenedioxythiophene): poly(4-styrene sulfonate) scaffolds was significantly higher than the Gel/bioactive glass scaffolds.

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导电 PEDOT:PSS 在硬组织支架中的影响：体外和体内研究

骨支架中导电成分的存在有助于促进细胞间的细胞内电信号传导，并在应用电磁刺激时改善骨愈合。在这项研究中，聚（3,4-亚乙基二氧噻吩）：聚（4-苯乙烯磺酸盐）作为一种生物相容性导电聚合物被加入由明胶（凝胶）和生物活性玻璃制成的硬组织支架中。体外结果表明，与没有聚（3,4-亚乙基二氧噻吩）：聚（4-苯乙烯磺酸盐）的支架组合物相结合，在孵育 14 天后，与不含聚（3,4-乙撑二氧噻吩）的支架相比，细胞活力提高了四倍以上。 (3,4-亚乙基二氧噻吩)：聚(4-苯乙烯磺酸盐)。体内研究证明了凝胶/生物活性玻璃/聚（3，