The liver is the largest important organ and the site for essential biochemical reactions and detoxifying toxic substances in the human body. Long-term, high-dose dexamethasone administration can cause severe alterations in liver function. Therefore, Thymus vulgaris leave extract possess a modulatory role on dexamethasone-induced hepatotoxicity by attenuating antioxidant defense system. By subcutaneous route, animals will receive three doses per week for 8 weeks of dexamethasone (0.1 mg/kg. b. wt.) concomitant with oral administration of thyme aqueous extract (500 mg/kg b.wt.). DXM treatment led to a marked increase in the liver function enzyme activities that are successfully ameliorated by thyme aqueous extract. Thyme natural antioxidants augmented the antioxidant defense system that overcomes oxidative stress caused by dexamethasone. Conversely, although dexamethasone-treated animals rose lipid peroxidation, thyme extract pretreatment did the reverse. Hepatotoxicity and oxidative stress caused by dexamethasone might improve by thyme natural antioxidants.

中文翻译：

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百里香提取物调节地塞米松诱导的肝损伤并恢复肝脏抗氧化氧化还原系统

肝脏是人体最大的重要器官，也是人体进行基本生化反应和解毒有毒物质的场所。长期、大剂量地塞米松给药可引起肝功能的严重改变。因此，百里香叶提取物通过减弱抗氧化防御系统对地塞米松诱导的肝毒性具有调节作用。通过皮下途径，动物将接受每周 3 次剂量的地塞米松（0.1 毫克/公斤体重），同时口服百里香水提取物（500 毫克/公斤体重）。DXM 治疗导致肝功能酶活性显着增加，百里香水提取物成功改善了这些酶活性。百里香天然抗氧化剂增强了抗氧化防御系统，克服了地塞米松引起的氧化应激。反过来，尽管地塞米松处理的动物脂质过氧化增加，百里香提取物预处理则相反。百里香天然抗氧化剂可能会改善地塞米松引起的肝毒性和氧化应激。