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Direct 3-D printing of Ti-6Al-4V/HA composite porous scaffolds for customized mechanical properties and biological functions.
Journal of Tissue Engineering and Regenerative Medicine ( IF 3.1 ) Pub Date : 2020-02-03 , DOI: 10.1002/term.3013
Tao Yi 1 , Changchun Zhou 2 , Liang Ma 3 , Lina Wu 2 , Xiujuan Xu 2 , Linxia Gu 4 , Yujiang Fan 2 , Guang Xian 1 , Hongyuan Fan 1 , Xingdong Zhang 2
Affiliation  

Customized scaffold plays an important role in bone tissue regeneration. Precise control of the mechanical properties and biological functions of scaffolds still remains a challenge. In this study, metal and ceramic biomaterials are composited by direct 3-D printing. Hydroxyapatite (HA) powders with diameter of about 25 μm and Ti-6Al-4V powders with diameter of 15-53 μm were mixed and modulated for preparing 3-D printing inks formulation. Three different proportions of 8, 10, and 25 wt.% HA specimens were printed with same porosity of 72.1%. The green bodies of the printed porous scaffolds were sintered at 1,150°C in the atmosphere of argon furnace and conventional muffle furnace. The porosities of the final 3-D-printed specimens were 64.3 ± 0.8% after linear shrinkage of 6.5 ± 0.8%. The maximum compressive strength of the 3-D-printed scaffolds can be flexibly customized in a wide range. The maximum compressive strength of these scaffolds in this study ranged from 3.07 to 60.4 MPa, depending on their different preparation process. The phase composition analysis and microstructure characterization indicated that the Ti-6Al-4V and HA were uniformly composited in the scaffolds. The cytocompatibility and osteogenic properties were evaluated in vitro with rabbit bone marrow stromal cells (rBMSCs). Differentiation and proliferation of rBMSCs indicated good biocompatibility of the 3-D-printed scaffolds. The proposed 3-D printing of Ti-6Al-4V/HA composite porous scaffolds with tunable mechanical and biological properties in this study is a promising candidate for bone tissue engineering.

中文翻译:

Ti-6Al-4V / HA复合多孔支架的直接3D打印,可实现定制的机械性能和生物学功能。

定制支架在骨组织再生中起重要作用。精确控制支架的机械性能和生物学功能仍然是一个挑战。在这项研究中,金属和陶瓷生物材料通过直接3D打印进行复合。将直径约25μm的羟基磷灰石(HA)粉末和直径15-53μm的Ti-6Al-4V粉末混合并调制以制备3-D印刷油墨配方。印刷了三种不同比例的8、10和25 wt。%的HA样品,孔隙率为72.1%。将印刷的多孔支架的生坯在氩气炉和常规马弗炉的气氛中在1150℃下烧结。线性收缩6.5±0.8%后,最终的3D打印样品的孔隙率为64.3±0.8%。3D打印支架的最大抗压强度可以在广泛的范围内灵活定制。这些支架的最大抗压强度在本研究中介于3.07至60.4 MPa之间,具体取决于它们的制备工艺。相组成分析和微观结构表征表明,Ti-6Al-4V和HA在支架中均匀地复合。用兔骨髓基质细胞(rBMSCs)在体外评估细胞相容性和成骨特性。rBMSCs的分化和增殖表明3D打印的支架具有良好的生物相容性。在这项研究中,拟议的具有可调节的机械和生物学特性的Ti-6Al-4V / HA复合多孔支架的3-D打印是骨组织工程的有希望的候选者。这些支架的最大抗压强度在本研究中介于3.07至60.4 MPa之间,具体取决于它们的制备工艺。相组成分析和微观结构表征表明,Ti-6Al-4V和HA在支架中均匀地复合。用兔骨髓基质细胞(rBMSCs)在体外评估细胞相容性和成骨特性。rBMSCs的分化和增殖表明3D打印的支架具有良好的生物相容性。在这项研究中,拟议的具有可调节的机械和生物学特性的Ti-6Al-4V / HA复合多孔支架的3-D打印是骨组织工程的有希望的候选者。这些支架的最大抗压强度在本研究中介于3.07至60.4 MPa之间,具体取决于它们的制备工艺。相组成分析和微观结构表征表明,Ti-6Al-4V和HA在支架中均匀地复合。用兔骨髓基质细胞(rBMSCs)在体外评估细胞相容性和成骨特性。rBMSCs的分化和增殖表明3D打印支架具有良好的生物相容性。在这项研究中,拟议的具有可调节的机械和生物学特性的Ti-6Al-4V / HA复合多孔支架的3-D打印是骨组织工程的有希望的候选者。相组成分析和微观结构表征表明,Ti-6Al-4V和HA在支架中均匀地复合。用兔骨髓基质细胞(rBMSCs)在体外评估细胞相容性和成骨特性。rBMSCs的分化和增殖表明3D打印支架具有良好的生物相容性。在这项研究中,拟议的具有可调节的机械和生物学特性的Ti-6Al-4V / HA复合多孔支架的3-D打印是骨组织工程的有希望的候选者。相组成分析和微观结构表征表明,Ti-6Al-4V和HA在支架中均匀地复合。用兔骨髓基质细胞(rBMSCs)在体外评估细胞相容性和成骨特性。rBMSCs的分化和增殖表明3D打印支架具有良好的生物相容性。在这项研究中,拟议的具有可调节的机械和生物学特性的Ti-6Al-4V / HA复合多孔支架的3-D打印是骨组织工程的有希望的候选者。rBMSCs的分化和增殖表明3D打印支架具有良好的生物相容性。在这项研究中,拟议的具有可调节的机械和生物学特性的Ti-6Al-4V / HA复合多孔支架的3-D打印是骨组织工程的有希望的候选者。rBMSCs的分化和增殖表明3D打印支架具有良好的生物相容性。在这项研究中,拟议的具有可调节的机械和生物学特性的Ti-6Al-4V / HA复合多孔支架的3-D打印是骨组织工程的有希望的候选者。
更新日期:2020-02-18
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