Bacillus cereus (B. cereus) endophthalmitis is a devastating intraocular infection primarily associated with post-traumatic injuries. The majority of these infections result in substantial vision loss, if not loss of the eye itself, within 12-48 h. Multifactorial mechanisms that lead to the innate intraocular inflammatory response during this disease include the combination of robust bacterial replication, migration of the organism throughout the eye, and toxin production by the organism. Therefore, the window of therapeutic intervention in B. cereus endophthalmitis is quite narrow compared to that of other pathogens which cause this disease. Understanding the interaction of bacterial and host factors is critical in understanding the disease and formulating more rational therapeutics for salvaging vision. In this review, we will discuss clinical and research findings related to B. cereus endophthalmitis in terms of the organism's virulence and inflammogenic potential, and strategies for improving of current therapeutic regimens for this blinding disease.

中文翻译：

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芽孢杆菌眼内炎的蜡样物质。

蜡状芽孢杆菌（B. cereus）眼内炎是一种破坏性眼内感染，主要与创伤后损伤有关。这些感染中的大多数会在12-48小时内导致视力丧失，甚至导致眼睛本身丧失。导致这种疾病先天性眼内炎性反应的多因素机制包括强大的细菌复制，生物体在整个眼中的迁移以及生物体产生毒素的组合。因此，与引起该疾病的其他病原体相比，蜡状芽胞杆菌眼内炎的治疗干预窗口非常狭窄。了解细菌和宿主因素的相互作用对于了解疾病和制定更合理的治疗方法以挽救视力至关重要。在这篇评论中