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Effects of enhanced depth imaging and en face averaging on optical coherence tomography angiography image quantification.
Graefe's Archive for Clinical and Experimental Ophthalmology ( IF 2.4 ) Pub Date : 2020-02-04 , DOI: 10.1007/s00417-020-04610-1
Keke Liu 1, 2 , Nihaal Mehta 1, 3 , A Yasin Alibhai 1 , Malvika Arya 1 , Osama Sorour 1, 4 , Akihiro Ishibazawa 1, 5 , Iksoo Byon 6, 7 , Caroline R Baumal 1, 8 , Andre J Witkin 1, 8 , Jay S Duker 1, 8 , SriniVas R Sadda 6, 7 , Nadia K Waheed 1, 8
Affiliation  

PURPOSE To examine the effects of enhanced depth imaging (EDI) and en face averaging on global vascular measurements of optical coherence tomography angiography (OCTA) images. METHODS All eyes were imaged with 3 mm × 3 mm fields centered at the fovea using the Carl Zeiss Cirrus 5000 spectral-domain OCTA, with and without EDI, and the Zeiss PLEX Elite 9000 swept-source OCTA. Vessel area density (VAD), vessel length (VL), and vessel diameter index (VDI) were calculated for the superficial capillary plexus (SCP) en face angiograms. For the choriocapillaris (CC), VAD and the number, total area, and average size of flow voids were calculated. These metrics were compared between SD- and SS-OCTA images, with and without en face averaging and EDI. RESULTS Both averaging and EDI had a significant effect on quantitative metrics. EDI images trended toward a decrease in SCP VAD. In the CC, EDI decreased average flow void size. Averaging increased CC VAD while decreasing number of flow voids, total flow void area, and average flow void size. With both averaging and EDI, SD-OCTA was not able to visualize as many CC flow voids, particularly of a smaller size, compared with SS-OCTA. CONCLUSIONS Averaging and EDI affect quantitative metrics from SCP and CC OCTA images. EDI resulted in a trend toward decreased VAD in SCP images. Averaging had a major effect on CC imaging. Even with the combination of EDI and en face averaging, SD-OCTA images do not appear to approximate SS-OCTA images in terms of quantitative metrics. This has implications for clinical and research use of SD-OCTA for retinal imaging.

中文翻译:

增强深度成像和面部平均对光学相干断层扫描血管造影图像量化的影响。

目的研究增强深度成像(EDI)的影响,并在光学相干断层扫描血管造影(OCTA)图像的整体血管测量中进行全脸平均。方法使用带有和不带有EDI的Carl Zeiss Cirrus 5000光谱域OCTA,以及Zeiss PLEX Elite 9000扫频源OCTA,以中心凹处为中心的3 mm×3 mm视野对所有眼睛进行成像。计算表面毛细血管丛(SCP)面血管造影照片的血管面积密度(VAD),血管长度(VL)和血管直径指数(VDI)。对于脉络膜毛细血管(CC),计算了VAD以及流动空隙的数量,总面积和平均大小。在有和没有面对面平均和EDI的情况下,将这些指标在SD和SS-OCTA图像之间进行了比较。结果平均和EDI均对定量指标产生重大影响。EDI图像趋向于降低SCP VAD。在CC中,EDI减小了平均流孔尺寸。平均增加CC VAD,同时减少流动空隙的数量,总流动空隙的面积和平均流动空隙的大小。与SS-OCTA相比,使用均值和EDI时,SD-OCTA无法可视化许多CC流动空隙,尤其是较小的CC流动空隙。结论平均和EDI影响SCP和CC OCTA图像的定量指标。EDI导致SCP图像VAD降低的趋势。平均对CC成像有重大影响。即使结合使用EDI和平均取景,SD-OCTA图像在定量指标上也似乎不接近SS-OCTA图像。这对SD-OCTA用于视网膜成像的临床和研究用途具有影响。平均增加CC VAD,同时减少流动空隙的数量,总流动空隙的面积和平均流动空隙的大小。与SS-OCTA相比,使用均值和EDI时,SD-OCTA无法可视化许多CC流动空隙,尤其是较小的CC流动空隙。结论平均和EDI影响SCP和CC OCTA图像的定量指标。EDI导致SCP图像VAD降低的趋势。平均对CC成像有重大影响。即使结合使用EDI和平均取景,SD-OCTA图像在定量指标上也似乎不接近SS-OCTA图像。这对SD-OCTA用于视网膜成像的临床和研究用途具有影响。平均增加CC VAD,同时减少流动空隙的数量,总流动空隙的面积和平均流动空隙的大小。与SS-OCTA相比,使用均值和EDI时,SD-OCTA无法可视化许多CC流动空隙,尤其是较小的CC流动空隙。结论平均和EDI影响SCP和CC OCTA图像的定量指标。EDI导致SCP图像VAD降低的趋势。平均对CC成像有重大影响。即使结合使用EDI和平均取景,SD-OCTA图像在定量指标上也似乎不接近SS-OCTA图像。这对SD-OCTA用于视网膜成像的临床和研究用途具有影响。与SS-OCTA相比,SD-OCTA无法看到许多CC流动空隙,尤其是较小的CC流动空隙。结论平均和EDI影响SCP和CC OCTA图像的定量指标。EDI导致SCP图像VAD降低的趋势。平均对CC成像有重大影响。即使结合使用EDI和平均取景,SD-OCTA图像在定量指标上也似乎不接近SS-OCTA图像。这对SD-OCTA用于视网膜成像的临床和研究用途具有影响。与SS-OCTA相比,SD-OCTA无法看到许多CC流动空隙,尤其是较小的CC流动空隙。结论平均和EDI影响SCP和CC OCTA图像的定量指标。EDI导致SCP图像VAD降低的趋势。平均对CC成像有重大影响。即使结合使用EDI和平均取景,SD-OCTA图像在定量指标上也似乎不接近SS-OCTA图像。这对SD-OCTA用于视网膜成像的临床和研究用途具有影响。就定量指标而言,SD-OCTA图像似乎不近似于SS-OCTA图像。这对SD-OCTA用于视网膜成像的临床和研究用途具有影响。就定量指标而言,SD-OCTA图像似乎不近似于SS-OCTA图像。这对SD-OCTA用于视网膜成像的临床和研究用途具有影响。
更新日期:2020-04-21
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