3-Amino-3,4-seco-lupa-4(23),20(29)-diene and its 3,28-bis (cyanoethyl) and 3-aminopropyl derivatives caused growth inhibition or death of nine human cancer cell lines. Leukemia, melanoma, and non-small-cell lung, colon, CNS, and kidney cancer cell lines were most sensitive to these compounds. Antitumor activity decreased with a tosyl group in the C-28 position or acetates on C-3 and C28.

中文翻译：

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3-Amino-3,4-Seco-Lupa-4(23),20(29)-Diene 衍生物的合成及抗肿瘤活性

3-Amino-3,4-seco-lupa-4(23),20(29)-diene 及其 3,28-bis（氰乙基）和 3-氨基丙基衍生物导致九种人类癌细胞系的生长抑制或死亡。白血病、黑色素瘤和非小细胞肺癌、结肠癌、中枢神经系统和肾癌细胞系对这些化合物最敏感。抗肿瘤活性随着 C-28 位置的甲苯磺酰基或 C-3 和 C28 上的乙酸盐而降低。