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Retraction of "Collateral Sensitivity of Multidrug-Resistant Cells to the Orphan Drug Tiopronin".
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2020-02-04 , DOI: 10.1021/acs.jmedchem.9b01794
Andrew S. Goldsborough , Misty D. Handley , Andres E. Dulcey , Kristen M. Pluchino , Pavitra Kannan , Kyle R. Brimacombe , Matthew D. Hall , Gary Griffiths , Michael M. Gottesman

A new Brief Article has been published (J. Med. Chem.2020, DOI: 10.1021/acs.jmedchem.9b00484). The authors retract this Article. While the data are correct and reproducible, postpublication research revealed mycoplasma contamination of the cell lines under investigation. In a separate Article, published simultaneously with this Retraction (“Mycoplasma Infection Mediates Sensitivity of Multidrug-Resistant Cell Lines to Tiopronin: A Cautionary Tale”, J. Med. Chem., DOI: 10.1021/acs.jmedchem.9b00484), we demonstrate that the hypersensitivity of multidrug-resistant cell lines to tiopronin is the result of mycoplasma infection. While the phenotype reported (hypersensitivity of mycoplasma-infected multidrug-resistant cancer cells to tiopronin compared to mycoplasma-infected parental cells) and data are accurate, we are retracting this Article and publishing the explanation to correct the scientific record. The original Article was published on June 9, 2011, and retracted on February 4, 2020. This article has not yet been cited by other publications.

中文翻译:

撤回“多药耐药细胞对孤儿药物硫普罗宁的间接敏感性”。

一个新的简短的文章已经发表(J.医学化学式。2020,DOI:10.1021 / acs.jmedchem.9b00484)。作者撤回本文。尽管数据是正确且可重复的,但发表后的研究表明被调查细胞系存在支原体污染。在与此撤回同时发表的另一篇文章中(“支原体感染介导了多药耐药性细胞系对硫普罗宁的敏感性:一个警示故事”,J。Med。Chem。,DOI:10.1021 / acs.jmedchem.9b00484),我们证明多药耐药细胞系对噻普罗宁的超敏性是支原体感染的结果。尽管所报告的表型(与支原体感染的亲代细胞相比,支原体感染的多药耐药性癌细胞对硫普罗宁过敏)和数据是准确的,但我们正在撤消本文,并发表解释以更正科学记录。原始文章于2011年6月9日发布,并于2020年2月4日撤回。其他出版物尚未引用此文章。
更新日期:2020-02-04
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