The anterior cingulate cortex (ACC), is known to be intimately involved in food-related motivational processes and their behavioral organization, primarily by evaluating hedonic properties of the relevant stimuli. In the present study, the involvement of cingulate cortical interleukin-1β (IL-1β) mediated mechanisms in a) gustation associated facial and somato-motor behavioral patterns of Wistar rats were examined in taste reactivity test (TR). In addition, b) conditioned taste aversion (CTA) paradigm was performed to investigate the role of these cytokine mechanisms in taste sensation associated learning processes, c) the general locomotor activity of the animals was observed in open field test (OPF), and d) the potentially negative reinforcing effect of IL-1β was examined in conditioned place preference test (CPP). During the TR test, species specific behavioral patterns in response to the five basic tastes were analyzed. Response rates of ingestive and aversive patterns of the cytokine treated and the control groups differed significantly in case of the weaker bitter (QHCl, 0.03 mM), and the stronger umami (MSG, 0.5 M) tastes. IL-1β itself did not elicit CTA, it did not interfere with the acquisition of LiCl induced CTA, and it also failed to cause place preference or aversion in the CPP test. In the OPF paradigm, however, significant differences were found between the cytokine treated and the control groups in the rearing and grooming, the number of crossings, and in the distance moved. Our results indicate the involvement of cingulate cortical IL-1β mechanisms in the control of taste perception and other relevant behavioral processes.

中文翻译：

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在大鼠的扣带皮层中双侧注射白细胞介素1β后，味觉反应性和其他行为改变受到干扰。

众所周知，前扣带回皮层（ACC）与食物相关的动机过程及其行为组织密切相关，主要是通过评估相关刺激的享乐特性来进行的。在本研究中，在味觉反应性测试（TR）中检查了扣带回皮质白介素1β（IL-1β）介导的机制与a）味觉相关的Wistar大鼠面部和躯体运动行为模式。此外，b）进行了条件性味觉厌恶（CTA）范例以研究这些细胞因子机制在味觉相关的学习过程中的作用，c）在开放视野试验（OPF）中观察到动物的总体运动活动，而d ）在条件性位置偏爱测试（CPP）中检查了IL-1β的潜在负增强作用。在TR测试期间，分析了针对五种基本口味的物种特定行为模式。在苦味较弱（QHCl，0.03 mM）和鲜味（MSG，0.5 M）更强的情况下，处理过的细胞因子和对照组的摄入和厌恶模式的反应率显着不同。IL-1β本身不会引发CTA，它不会干扰LiCl诱导的CTA的获得，并且也不会在CPP测试中引起位置偏爱或反感。但是，在OPF范式中，处理的细胞因子与对照组之间在饲养和修饰，杂交次数和移动距离方面存在显着差异。我们的结果表明扣带回皮质IL-1β机制参与味觉控制和其他相关行为过程的控制。