Parthenolide (PTL) is a natural compound with anti-inflammatory and antioxidant properties and is an active ingredient extracted from the medicinal plant Tanacetum parthenium. ACT001 is derived from parthenolide and is a fumarate form of dimethylaminomylide (DMAMCL). Its effect is equivalent to that of PTL, but it is more stable in plasma and has lower acquisition costs. Related reports indicate that NLRP3-mediated neuroinflammation is involved in the progression of Parkinson's disease (PD). In our research, we explored whether ACT001 alleviates NLRP3-mediated neuroinflammation in PD mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Our results revealed that ACT001 reduces movement impairment and cognitive deficit in PD mice. In addition, it alleviates dopaminergic neurodegeneration in the nigrostriatal pathway and inhibits oxidative stress, the inflammatory response and activation of the NLRP3 inflammasome in the midbrain of MPTP-induced PD mice. Moreover, it attenuates microglial activation in the nigrostriatal pathway. Overall, our study showed that ACT001 alleviates NLRP3-mediated neuroinflammation in PD mice induced by MPTP.

中文翻译：

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在小鼠中MPTP诱发的帕金森病中，二甲氨基甲酰胺（DMAMCL，即ACT001）的抗神经炎作用与NLRP3γ体的减毒有关。

爬山虎精（PTL）是一种具有抗炎和抗氧化性能的天然化合物，是从药用植物艾菊（Tanacetum parthenium）中提取的有效成分。ACT001衍生自小白菊内酯，是富马酸酯形式的二甲基氨基Mylide（DMAMCL）。它的效果与PTL相当，但是在血浆中更稳定，并且采购成本更低。相关报道表明，NLRP3介导的神经炎症与帕金森氏病（PD）的进展有关。在我们的研究中，我们探讨了ACT001是否减轻1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的PD小鼠中NLRP3介导的神经炎症。我们的结果表明，ACT001可以减少PD小鼠的运动障碍和认知缺陷。此外，它减轻了黑质纹状体途径中的多巴胺能神经变性，并抑制了MPTP诱导的PD小鼠中脑的氧化应激，炎症反应和NLRP3炎性小体的激活。此外，它减弱了黑质纹状体途径中的小胶质细胞活化。总体而言，我们的研究表明，ACT001可以减轻MPTP诱导的PD小鼠中NLRP3介导的神经炎症。